Search for dissertations about: "plasminogen activator inhibitor type-1"

Showing result 1 - 5 of 21 swedish dissertations containing the words plasminogen activator inhibitor type-1.

2. 1. Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements

   Author : Peter Hägglöf; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; PAI-1 serpin RCL complex formation DDEM Intramolecular distance; Biomedicin; Microbiology; Mikrobiologi; medicinsk biokemi; Medical Biochemistry;

   Abstract : Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. READ MORE

4. 2. Food intake, fibrinolysis and risk factors for cardiovascular disease : studies with special focus on plasminogen activator inhibitor type 1 (PAI-1)

   Author : Birgitta Sundell-Rånby; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body build; diet; fiber; fibrinolysis; glucose; insulin; lipids; obesity; plasminogen activator inhibitor;

   Abstract : Elevated plasminogen activator inhibitor (PAI-1) activity levels, hyperlipemia, hypertension, impaired glucose tolerance and obesity, in particular central obesity, are all related to increased risk for the development of cardiovascular disease.Some risk factors are known to be and shown to be influenced by dietary habits. READ MORE

5. 3. Mechanisms and effects of low plasminogen activator inhibitor type 1 activity

   Author : Anna Ågren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Bleeding; body mass index; epidemiology; plasminogen activator inhibitor; surgery; prostate; fibrinolysis; C-peptide; CRP; IL-6; proinsulin;

   Abstract : Bleeding diathesis is a common reason for investigation of the haemostatic system and in about 50% of the cases an abnormality is found. Plasminogen activator inhibitor type 1 (PAI-1) is an inhibitor of tissue- and urokinase plasminogen activator (tPA/uPA). READ MORE

6. 4. Regional fluxes of tissue plasminogen activator in porcine endotoxemia

   Author : Annette Nyberg; Göteborgs universitet; []
   Keywords : pig; endotoxin; tissue type plasminogen activator; plasminogen activator inhibitor; tumor necrosis factor ?;

   Abstract : Formation of fibrin clots in the microcirculation during severe sepsis contributes to organ failure, frequently involving the lungs and the splanchnic organs. Tissue type plasminogen activator, tPA, is the key activator of intravascular fibrinolysis with plasminogen activator inhibitor type-1, PAI-1, as its main inhibitor. READ MORE

7. 5. On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease

   Author : Anna Tjärnlund-Wolf; Göteborgs universitet; []
   Keywords : tissue-type plasminogen activator; plasminogen activator inhibitor type-1; polymorphism; endothelium; Sp1; gene expression; myocardial infarction; ischemic stroke;

   Abstract : Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus (-7,351C>T), located within a GC-box in the retinoic acid (RA) and steroid hormone responsive t-PA enhancer. READ MORE