Search for dissertations about: "plasminogen angiogenesis"

Showing result 1 - 5 of 13 swedish dissertations containing the words plasminogen angiogenesis.

  2. 1. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition

    Author : Maria Sandström; Roger Henriksson; Mikael Johansson; Anja Smits; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; angiogenesis; VEGF; tyrosinekinaseinhibitor; ZD6474; plasminogenactivator; tPA; uPA; proteomics; Oncology; Onkologi;

    Abstract : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. READ MORE

  4. 2. Growth factor regulation of the urokinase plasminogen activator (uPA) system in human endometrium, and the significance of uPA receptor activation in endometrial angiogenesis

    Author : Tove Sandberg; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics; endothelial cell migration; angiogenesis; uPA:PAI-1 complex; uPAR; TGF-beta; PAI-1; EGF; uPA; Growth factor; gynaecology; andrology; reproduction; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet;

    Abstract : The purpose of this thesis was to examine the role of growth factors and the urokinase plasminogen activator (uPA) system in human endometrial angiogenesis. Growth factors as well as progesterone increased expression of the main inhibitor of uPA (PAI-1) in primary cultures of endometrial stromal cells. READ MORE

  5. 3. Biochemical and Epidemiological Studies of Early-Onset and Late-Onset Pre-Eclampsia

    Author : Anna-Karin Wikström; Matts Olovsson; Ulf Eriksson; Solveig Norden-Lindeberg; Göran Berg; Uppsala universitet; []
    Keywords : Obstetrics and gynaecology; pre-eclampsia; proteinuria; albumin-creatinine ratio; ischaemic heart disease; angiogenesis; sFlt1; oxidative stress; isoprostane; PAI-1; PAI-2; Obstetrik och kvinnosjukdomar;

    Abstract : Biochemical and epidemiological aspects of pre-eclampsia were investigated, with the main focus on possible pathophysiological differences between early-onset and late-onset disease.In pre-eclamptic women poor correlation was found between albumin-creatinine ratio (ACR) in a random urine sample and total amount of albumin in a 24-hour urine collection. READ MORE

  6. 4. Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements

    Author : Peter Hägglöf; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; PAI-1 serpin RCL complex formation DDEM Intramolecular distance; Biomedicin; Microbiology; Mikrobiologi; medicinsk biokemi; Medical Biochemistry;

    Abstract : Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. READ MORE

  7. 5. Angiostatic mechanisms of endogenous angiogenesis inhibitors

    Author : Niina Veitonmäki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; tumor growth; angiostatin; K 1 - 5; adiponectin; hTERT; p16;

    Abstract : Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor nearly 10 years ago. The structure of angiostatin consists of the first three/four kringle (K1-3/K1-4) domains of plasminogen. READ MORE