Search for dissertations about: "platelets aggregation"

Showing result 1 - 5 of 61 swedish dissertations containing the words platelets aggregation.

  2. 1. Platelets : intracellular signalling and cellular interaction

    Author : Magnus Grenegård; Hans Gyllenhammar; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Activation of platelets is essential to prevent excessive blood loss at the site of vascular injury. These highly reactive cell fragments are also involved in several pathological conditions, in particular arterial thrombosis, which, in the coronary vessels, can lead to reduced blood flow, vessel occlusion and myocardial infarction. READ MORE

  4. 2. Role of GPIbαlpha Clustering and N-linked Carbohydrates in the Clearance of Refrigerated Platelets

    Author : Emma Josefsson; Göteborgs universitet; []
    Keywords : Platelets; GPIbalpha; alphaMbeta2; phagocytosis; refrigerated platelets;

    Abstract : The thesis focuses on understanding the mechanisms by which: 1) the macrophage alphaM-subunit recognizes betaN-acetylglucosamine (betaGlcNAc) residues on the von Willebrand factor receptor complex ((GPIbalpha,beta/IX)2V or vWfR) on refrigerated platelets and 2) refrigeration changes vWfR to elicit recognition through alphaMbeta2. Until recently, the only well-established mechanisms affecting platelet survival were antibody-mediated platelet clearance, consumption of platelets by coagulation reactions, and loss due to massive bleeding. READ MORE

  5. 3. Platelets in inflammation : Role of complement protein C1q, C-reactive proteinand toll-like receptors

    Author : Caroline Skoglund; Torbjörn Bengtsson; Jonas Wetterö; Pentti Tengvall; David Erlinge; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Platelets are proven essential in haemostasis, however, they are now also increasingly recognized as cells with important immunomodulatory properties, e.g. through interaction with leukocytes and several species of bacteria and by release inflammatory mediators upon activation. READ MORE

  6. 4. Fibrinogen, platelet and factor XIII supplementation in cardiac surgery: In vitro and in vivo studies

    Author : Caroline Andersson Shams Hakimi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fibrinogen; platelets; factor XIII; platelet aggregation; clot formation; cardiac surgery;

    Abstract : Background: There is a high risk of bleeding complications in cardiac surgery. Fibrinogen and platelet concentrates are often used to treat perioperative bleeding, but there is little information about its efficacy. READ MORE

  7. 5. Streptococci and Platelets - A Study of Host-Pathogen Interaction Dynamics

    Author : Lisbeth Svensson; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; host-pathogen interactions; bacterial entrapment; disaggregation; aggregation; platelet activation; Streptococci;

    Abstract : Invasive infections remains one of the leading causes of death due to infections over the world, and efficient treatment remains elusive. One of the major causes of sepsis and other invasive infections is pathogenic streptococci that cause a wide range of clinical manifestations in humans. READ MORE