Search for dissertations about: "polyadenylation"

Showing result 1 - 5 of 27 swedish dissertations containing the word polyadenylation.

  1. 1. Regulation of Human Papillomavirus Type 16 mRNA Splicing and Polyadenylation

    Author : Xiaomin Zhao; Stefan Schwartz; Barklie Clements; Uppsala universitet; []
    Keywords : Medical sciences; human papillomavirus type 16; gene regulation; splicing; polyadenylation; 3 UTR; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Abstract : Human papillomavirus type 16 (HPV-16) is the major causative agent of cervical cancer. The life cycle of this oncogenic DNA tumour virus is strictly associated with the differentiation program of the infected epithelial cells. Expression of the viral capsid genes L1 and L2 can only be detected in the terminally differentiated epithelial cells. READ MORE

  2. 2. The Role of Polyadenylation in Human Papillomavirus Type 16 Late Gene Expression

    Author : Daniel Öberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; HPV-16; polyadenylation; mRNA stability; codon usage; hnRNP H; DSE; splicing; negative element; RNA processing; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : High-risk type human papillomaviruses (HPVs) are associated with cancer. HPVs are strictly epitheliotropic and infect basal cell layers, establishing a life cycle strongly linked to the differentiation stage of the infected cells. The viral capsid late genes, L2 and L1, are only expressed in terminally differentiated epithelium. READ MORE

  3. 3. Regulation of RNA Processing in Human Papillomavirus Type 16

    Author : Margaret Rush; Stefan Schwartz; Jörgen Kjems; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; RNA processing; human papillomavirus; HPV-16; alternative splicing; polyadenylation; exonic splicing enhancer; 3 UTR; upstream polyadenylation element; SR proteins; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. HPV-16 gene expression is tightly linked to the differentiation programme of the infected epithelium. Expression of the late genes, L1 and L2, encoding the capsid proteins, is delayed until the more terminally differentiated cells. READ MORE

  4. 4. Functional aspects on the Epstein-Barr virus nuclear antigen 5

    Author : Martin Dufva; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Epstein-Barr Virus; EBV; B-cell; transformation; cDNA array; polyadenylation; transcription; cell cycle; apoptosis; two-hybrid system.;

    Abstract : The Epstein-Barr virus (EBV) infects resting B-cells. This leads to an EBV driven transformation of the resting B-cell into a cell with an activated B-cell phenotype that proliferates indefinitely in vitro. Epstein-Barr Nuclear antigen 5 (EBNA5) is one out of six EBV encoded protein involved in transformation of resting B-cell. READ MORE

  5. 5. Regulation of Mammalian Poly(A) Polymerase Activity

    Author : Ann-Charlotte Thuresson; Barklie Clements; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; poly A polymerase; PAP; polyadenylation; isoforms; phosphorylation; alternative splicing; CPSF interaction; aminoglycosides; Biomedicin; Microbiology; Mikrobiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Poly(A) polymerase (PAP) is the enzyme catalyzing the synthesis of the adenine tail to the 3’-end of mRNA. This A-tail is present on the majority of the primary RNA transcripts of protein-coding genes, and is important for mRNA stability, export to the cytoplasm and translation. Therefore, PAP is a key regulator of eukaryotic gene expression. READ MORE