Search for dissertations about: "polychlorinated biphenyls"

Showing result 21 - 25 of 81 swedish dissertations containing the words polychlorinated biphenyls.

  2. 21. Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls

    Author : Yvonne Bager; Karolinska Institutet; Karolinska Institutet; []
    Keywords : gap junctional intercellular communication; phosphorylation; tumour promotion; alteredhepatic foci; rat liver; potency; PCBs; TCDD.Doctoral Thesis Yvonne Bager;

    Abstract : Chemically induced carcinogenesis is a multi-stage process that can be divided into at least three major stages, initiation, promotion and progression. The promotion stage involves clonal expansion of genetically altered cells (i.e. initiated cells). READ MORE

  4. 22. Some hormonal factors in the etiology of endometrial cancer

    Author : Elisabete Weiderpass; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endometrial neoplasms; hormone replacement therapy; estrogens; progestins; contraceptive agents; organochlorines; pesticides; polychlorinated biphenyls; estrogen receptor alfa polymorphisms;

    Abstract : The main purpose of this dissertation was to study the impact of some hormone-related factors in the etiology of endometrial neoplasms, i.e. hormone replacement therapy, use of oral contraceptives, serum levels of 20 different organochlorine substances, and polymorphisms in the estrogen receptor alpha (ER) gene. READ MORE

  5. 23. Regulation and function of the Clara cell secretory protein

    Author : Magnus Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung Clara cells Uteroglobin Polychlorinated biphenyls Rat Mouse Hu-man Fetal development Glucocorticoids Cells; cultured Gene expression regulation CEBP Calcium Protein conformation Computer simulation Mutagenesis; site-directedCalcium binding pr;

    Abstract : The Clara cell secretory protein (CCSP; also known as Polychlorinated Biphenyl-binding protein (PCB-BP) or Uteroglobin) is specifically produced and secreted into the distal airway lumen by the non-ciliated Clara cell. It is a low molecular weight homodimeric protein and binds certain metabolites of PCBs as well as progestins and calcium. READ MORE

  6. 24. Persistent Organic Pollutants and the Environment : A Chemometric Approach to the Study of Halogenated Aromatics

    Author : Tomas Öberg; Bo Bergbäck; Bo Wiman; Jaakko Paasivirta; Högskolan i Kalmar; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi; Environmental Chemistry; Miljökemi;

    Abstract : Concern is growing about the environmental and health effects of persistent organic pollutants (POPs), many of which are halogenated aromatic compunds. The research reported in this thesis focuses on factors determining their behaviour and release into the environment. READ MORE

  7. 25. Organohalogen contaminants in wildlife from the Yangtze River Delta : Development of methods and assessments of legacy and emerging persistent organic pollutants

    Author : Ge Yin; Åke Bergman; Gang Yu; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Organochlorine pesticides; flame retardants; chlorinated paraffins; PCBs; PCDEs; PBDEs; PCDD Fs; dicofol; environmental monitoring; bioindicator; shellfish; snail; bird eggs; miljökemi; Environmental Chemistry;

    Abstract : Rapid economic development has occurred during the past few decades in China with the Yangtze River Delta (YRD) area as one of the most progressive areas. The urbanization, industrialization, agricultural and aquaculture activities result in extensive production and application of chemicals. READ MORE