Search for dissertations about: "polymorphism coronary heart disease"

Showing result 1 - 5 of 16 swedish dissertations containing the words polymorphism coronary heart disease.

  2. 1. Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies

    Author : Jaana Gustavsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coronary heart disease; gene-lifestyle interaction; APOE; FTO; GHRL; smoking; physical activity; diet; obesity;

    Abstract : Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on apolipoprotein E (APOE), fat mass and obesity-related (FTO) and ghrelin/obestatin prepropeptide (GHRL) genes, as well as smoking, physical activity and diet. READ MORE

  4. 2. On the genetic variation of interleukin-6 in health and coronary heart disease

    Author : Marie Björnstedt Bennermo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atherosclerosis; coronary heart disease; factor VIIa; genetics; inflammation; interleukin-6; pathogen burden; polymorphism;

    Abstract : There is increasing evidence that inflammation plays an important role in the development of atherosclerosis and coronary heart disease (CHD). Prospective studies on healthy individuals and on patients with unstable angina pectoris or non-Q-wave myocardial infarction have shown that individuals with high interleukin-6 (IL-6) concentrations have an increased risk of myocardial infarction and death due to cardiovascular disease. READ MORE

  5. 3. Functional characterisation of polymorphisms in candidate genes for coronary heart disease

    Author : Ferdinand M van't Hooft; Karolinska Institutet; Karolinska Institutet; []
    Keywords : fibrinogen; coagulation factor VII; apolipoprotein B; hepatic lipase; angiotensinogen; atherosclerosis; low density lipoprotein; high density lipoprotein; blood pressure;

    Abstract : Coronary heart disease (CHD) is a multifactorial disorder. Several important risk factors, in particular cigarette smoking, hypertension, hypercholesterolaemia, reduced high density lipoprotein (HDL) cholesterol concentration and hyperglycaemia, have been defined. READ MORE

  6. 4. Risk factors in ischemic stroke

    Author : Katarina Jood; Göteborgs universitet; []
    Keywords : stroke; ischemic stroke subtypes; genetics; polymorphism; fibrinolysis; obesity; stress;

    Abstract : Ischemic stroke is a complex disease in which environmental and genetic factors make about equal contributions to the etiology. However, knowledge regarding the molecular basis of the genetic influence and the impact of specific lifestyle factors is limited. READ MORE

  7. 5. Coffee and gene interaction. The effect on methionine and lipid metabolism

    Author : Elisabeth Strandhagen; Göteborgs universitet; []
    Keywords : coffee; homocysteine; cholesterol; folate; pyridoxine; MTHFR; APOE; gene; polymorphism; interaction;

    Abstract : Background: Different dietary factors influence the risk of coronary heart disease (CHD), most likely in an interaction with genetic polymorphisms. The knowledge about such interactions is insufficient. Some observational studies have shown an association between coffee and CHD, others have not. Coffee consumption affects some CHD risk factors, e. READ MORE