Search for dissertations about: "polypeptide"
Showing result 21 - 25 of 236 swedish dissertations containing the word polypeptide.
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21. Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications
Abstract : In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. READ MORE
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22. Development of Peptide Binders : Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1
Abstract : In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen polypeptides, a small binding molecule can evolve into a polypeptide binder with increased affinity and selectivity. READ MORE
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23. Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins
Abstract : This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. READ MORE
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24. Cooperative Reactive Sites in Designed Helix-Loop-Helix Polypeptide Catalysts
Abstract : Designed polypeptides, which fold into helix-loop-helix motifs and dimerise to four-helix bundles have been used as scaffolds for the introduction of catalytic activity for the hydrolysis of p-nitrophenyl esters. The reactive sites were based on the reactivity of histidine, and two His residues separated by four residues in the sequence was shown to be the minimal reactive site for the efficient hydrolysis of nitrophenyl esters. READ MORE
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25. Cloning and characterization of neuropeptide Y receptors of the Y1 subfamily in mammals and fish
Abstract : Neuropeptide Y (NPY) is an abundant neurotransmitter in the nervous system and forms a family of evolutionarily related peptides together with peptide YY (PYY), pancreatic polypeptide (PP) and polypeptide Y (PY). These peptides are ligands to a family of receptors that mediate a wide range of physiological effects including stimulation of appetite. READ MORE