Search for dissertations about: "polypeptide"

Showing result 6 - 10 of 236 swedish dissertations containing the word polypeptide.

  2. 6. POLYPEPTIDES - STRUCTURES AND INTERACTIONS IN MONOLAYERS AND AQUEOUS SOLUTIONS

    Author : Helen Sjögren; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Fysikalisk kemi; tyrosine ; co-poly-L lysine; phenylalanine ; co-poly-L- lysine; poly-L-glutamate; poly-L-lysine; poly-L-valine; poly-L-isoleucine; poly-gamma-methyl-L-glutamate; poly-L-leucine; monolayer; Langmuir-Blodgett film; CD spectroscopy; random coil; alpha-helix; surfactant stabilisation; polypeptide; polyamino acid;

    Abstract : The aim of this thesis work is to understand and be able to control polypeptide conformation and interactions at interfaces and in solution by changing the solution conditions. For this purpose simple model polypeptides, so-called polyamino acids, have been investigated at the air-liquid interface, as well as in aqueous solutions. READ MORE

  4. 7. High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation

    Author : Xiaojiao Sun; Lars Baltzer; Thomas Norberg; Ulf Nilsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide; conjugates; D-dimer; myeloperoxidase; chitinase;

    Abstract : This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. READ MORE

  5. 8. Pituitary adenylate cyclase activating polypeptide : Expression and neurotrophic activity in the rat brain

    Author : Ylva Skoglösa; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; in situ hybridisation; rat; TBI; BDNF; NGF; GDNF; PACAP; PRI; TUNEL; apoptosis; CNS; PNS; neuropeptides; neurotrophic factors; reactive oxygen species; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Neurotrophic factors play an important role in regulating naturally occurring cell death during neurogenesis. In addition to classical neurotrophic factors, some neurotransmitters and neuropeptides have been shown to exhibit neurotrophic activities. READ MORE

  6. 9. Gastric Inhibitory Polypeptide in the brain

    Author : Jenny Nyberg; Göteborgs universitet; []
    Keywords : neural progenitor cells; neural stem cells; hippocampus; cell proliferation; GIP; neuropeptides; insulinotropic; gastrointestinal;

    Abstract : The hippocampus is an area of active cell proliferation and neurogenesis within the adult mammalian brain. Adult neurogenesis is of great importance for the brain, since it increases neuroplasticity and the ability to respond to environmental stimuli. READ MORE

  7. 10. Studies on Islet Amyloid Polypeptide Aggregation : From Model Organism to Molecular Mechanisms

    Author : Sebastian Schultz; Gunilla Torstensdotter Westermark; Anne Simonsen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The proper folding of a protein into its defined three--?dimensional structure is one of the many fundamental challenges a cell encounters. A number of tightly controlled pathways have evolved to assist in the proper folding of a protein, but also to aid in the removal of misfolded proteins. READ MORE