Search for dissertations about: "polyprotein"

Showing result 1 - 5 of 11 swedish dissertations containing the word polyprotein.

  2. 1. Topology and membrane rearrangements of the hepatitis C virus protein NS4B

    Author : Marika Lundin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C virus; NS4B; NS5A; topology; posttranslational translocation membrane rearrangements; endoplasmic reticulum; polyprotein; membrane protein; membrane associated foci; oligomerization; viral replication; replicon; replication complex; mutations; immunoprecipitation;

    Abstract : Hepatitis C virus (HCV) is a major cause of chronic liver disease and viral hepatitis around the world. Approximately 180 million people or 3% of the world's population are infected with the virus. READ MORE

  4. 2. Characterizing important flavivirus-host interactions : Replication, assembly, restriction factors and vaccine development

    Author : Pham Tue Hung Tran; Magnus Johansson; Wessam Melik; Naveed Asghar; Sören Andersson; Laurent Chatel-Chaix; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flaviviruses; virus-host cell interaction; lunapark; ESCRT; ALIX; CHMP4A; ISG15; TRIMs; replicon virus-like particles; vaccine;

    Abstract : The genus Flavivirus (family Flaviviridae) consists of important zoonotic viruses that cause morbidity and mortality worldwide. These viruses are enveloped and have a positive-sense single-stranded RNA genome encoding a polyprotein. READ MORE

  5. 3. Degradomics : a study of the cellular proteolytic landscape in enterovirus infections

    Author : Sebastian Kapell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The common human pathogen, enteroviruses (EVs) are a genus of single stranded RNA viruses that include Coxsackie B virus (CVBs). The viral RNA encodes a polyprotein containing two viral proteases 2Apro and 3Cpro, that process the polyprotein into structural and non-structural proteins during virus replication. READ MORE

  6. 4. Alphavirus-host interactions : how to unravel the proviral activity of G3BP

    Author : Benjamin Götte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically distinguished into Old World and New World alphaviruses. READ MORE

  7. 5. Ljungan Virus Replication in Cell Culture

    Author : Jens-Ola Ekström; Kjell Edman; Glyn Stanway; Högskolan i Kalmar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ljungan virus; picornavirus; parechovirus; 5 - RACE; 5 -end; infectious cDNA clone; real time PCR; virus purification; virion stability; disinfection; aphthovirus-like 2A; Virology; Virologi; Mikrobiologi; Microbiology;

    Abstract : Ljungan virus (LV) is a recently identified picornavirus of the genus Parechovirus. LV has been isolated from voles trapped in Sweden and also in the United States. LV infected small rodents may suffer from diabetes type 1 and type 2 like symptoms, myocarditis and encephalitis. READ MORE