Search for dissertations about: "poorly water-soluble compounds"

Showing result 1 - 5 of 6 swedish dissertations containing the words poorly water-soluble compounds.

2. 1. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

   Author : Linda C. Alskär; Christel Bergström; Brendan Griffin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE

4. 2. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

   Author : Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. READ MORE

5. 3. Predicting oral performance of lipid-based formulations using in vitro methods

   Author : Oliver Hedge; Christel Bergström; Frédéric Carriere; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation s ; SEDDS; artificial membrane s ; cell monolayer s ; oral drug delivery; lipolysis; permeation; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. READ MORE

6. 4. Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica

   Author : Xin Xia; Alfonso E. Garcia-Bennett; Xiaodong Zou; Göran Frenning; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; mesoporous silica; drug delivery; solubility enhancement; active pharmaceutical ingredients; oral toxicity; confinement; crystallization; pharmaceutical excipients; bioavailability; Inorganic Chemistry; oorganisk kemi;

   Abstract : Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. READ MORE

7. 5. Experimental and Computational Predictions of Drug Solubility in Human Gastrointestinal Fluids

   Author : Jonas H. Fagerberg; Christel A. S. Bergström; Gert Ragnarsson; Bradley D. Anderson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : The aqueous solubility of a drug is viewed as a pivotal property for its oral absorption since only dissolved molecules can permeate the gut wall and reach the systemic circulation. The fluids in the intestine, however, do not only consist of water and therefore poor water solubility may not necessarily imply a poor solubility in the intestinal fluids and resulting low bioavailability. READ MORE