Search for dissertations about: "population pharmacokinetics"
Showing result 11 - 15 of 74 swedish dissertations containing the words population pharmacokinetics.
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11. Applied Population Pharmacokinetic/ Pharmacodynamic Modeling of Antiretroviral and Antimalarial Drug Therapy
Abstract : HIV/AIDS and malaria are two major global infectious diseases. Although better drugs against these conditions are becoming more available, dosages may not always be optimal with respect to effectiveness, safety, cost or convenience of administration. READ MORE
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12. Modelling and Simulation to Improve Antimalarial Therapy
Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE
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13. Pharmacometric Models for Improved Prediction of Myelosuppression and Treatment Response in Oncology
Abstract : Chemotherapy plays an important role in the treatment of cancer. However, these drugs also cause death of non-malignant cells, resulting in severe side-effects. In addition, drug resistance may exist. Predictive tools for dose and drug selection are therefore warranted. READ MORE
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14. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies
Abstract : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. READ MORE
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15. Pharmacokinetics of antidepressant drugs : naturalistic and clinical trials
Abstract : Depression is a major public health problem and it is predicted to be the second leading cause of disease burden by the year 2020. The pharmacological treatment period for major depressive disorder (MDD) is relatively long and sometimes prophylactic over many years. READ MORE