Search for dissertations about: "population pharmacokinetics"
Showing result 16 - 20 of 74 swedish dissertations containing the words population pharmacokinetics.
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16. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs
Abstract : Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. READ MORE
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17. Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV
Abstract : Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for tuberculosis consists of rifampicin, isoniazid, pyrazinamide and ethambutol. READ MORE
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18. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections
Abstract : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. READ MORE
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19. In vitro and in vivo studies of artemisinin endoperoxides
Abstract : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. READ MORE
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20. Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
Abstract : Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. READ MORE