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Showing result 1 - 5 of 266 swedish dissertations matching the above criteria.

  2. 1. Developing a Porcine Model to Study the Glymphatic System

    Author : Nicholas Bechet; Glia-Immune Interactions; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glymphatic system; cerebrospinal fluid; Porcine; in vivo imaging; amyloid beta; Alzheimer disease;

    Abstract : The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. READ MORE

  4. 2. Cytochrome P450 Enzymes in Bile Acid Biosynthesis and Fatty Acid Metabolism : Studies on Members of the Porcine CYP4A and CYP8B Subfamilies

    Author : Kerstin Lundell; Kjell Wikvall; Ronnie Hansson; Stefan Alexson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; cytochrome P450; bile acids; fatty acids; CYP4A; CYP8B; genome; porcine; hyocholic acid; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The present investigation is devoted to studies on porcine members of the cytochrome P450 4A (CYP4A) and CYP8B1 subfamilies, which are involved in bile acid biosynthesis and fatty acid metabolism. Hyocholic acid is considered to fulfil the requirements for trihydroxy bile acids in the domestic pig (Sus scrofa) in the absence of cholic acid. READ MORE

  5. 3. Porcine myocardial ischemia-reperfusion studies on cardioprotection, ventricular arrhythmia and electrophysiology

    Author : Jacob Odenstedt; Göteborgs universitet; []
    Keywords : porcine; myocardial ischemia; ventricular arrhythmia; sudden cardiac death; electrophysiology; vectorcardiography; endocardial mapping; spinal cord stimulation;

    Abstract : Background: Coronary artery disease is the primary cause of death in adults in the industrialised world and ventricular fibrillation associated with myocardial ischemia is the main cause of sudden cardiac death. Restoration of blood flow and preservation of myocardial integrity throughout ischemia and reperfusion is essential to improve clinical outcome. READ MORE

  6. 4. Novel Interventions in Cardiac Arrest : Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol,  Endothelin and Nitric Oxide In Porcine Resuscitation Models

    Author : Frank Zoerner; Fredrik Lennmyr; Cécile Martijn; Lars Wiklund; Sven Erik Gisvold; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; restoration of spontaneous circulation; ROSC; cardiopulmonary resuscitation; CPR; cardiac arrest; methylene blue; MB; S-PBN; mild therapeutic hypothermia; MTH; targeted temperature management; TTM; endothelin; ET-1; ECE-1; ETAR; ETBR; nitric oxide; NO; nitric oxide synthase; NOS; eNOS; iNOS; nNOS; porcine; amiodarone; hypovolemia; milrinone; vasopressin; esmolol; epinephrine; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård; Medical Cell Biology; Medicinsk cellbiologi; Kardiologi; Cardiology;

    Abstract : It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). READ MORE

  7. 5. On the effect of repetitive loading on the spine of young elite athletes. Clinical and experimental studies

    Author : Olof Thoreson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spine; intervertebral disc; athlete; young adult; low back pain; magnetic resonance imaging; porcine; repetitive loading; failure; fatigue;

    Abstract : Introduction: The human spine is exposed to many different loads during daily activities and especially during sporting activities. The spine has different biomechanical properties during the lifetime and thereby responds differently to repetitive and sudden loads. READ MORE