Search for dissertations about: "pore-forming toxins"

Showing result 1 - 5 of 9 swedish dissertations containing the words pore-forming toxins.

2. 1. Studies of pore-forming bacterial protein toxins in Escherichia coli

   Author : Constance Enow; Bernt Eric Uhlin; Sun Nyunt Wai; Mikael Rehn; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molekylärbiologi; Molecular Biology;

   Abstract : Escherichia coli, a Gram-negative bacterium, which can be classified into three groups: the commensal, intestinal pathogenic (IPEC) and extra-intestinal pathogenic (ExPEC) E. coli. The cytolysin A (ClyA) protein, a 34-kDa pore-forming toxin, encoded by a gene found in both non-pathogenic and pathogenic E. READ MORE

4. 2. Pathogen entry mechanisms and endocytic responses to plasma membrane damage

   Author : Lars Nygård Skalman; Richard Lundmark; Kristian Riesbeck; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocytosis; plasma membrane; pathogens; virus; bacterial membrane vesicles; Helicobacter pylori; adenovirus 37; listeriolysin O; pore-forming toxins; membrane repair;

   Abstract : Endocytosis is a fundamental cellular process by which cells transport material from the outside to the inside of the cell through the formation of membrane invaginations that bud off from the plasma membrane. This process is important for nutrient uptake, regulating cell surface receptors and the overall plasma membrane composition. READ MORE

5. 3. Novel signaling pathways : induced by bacterial toxins in eukaryotic cells

   Author : Camilla Oxhamre; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Inflammation is the process by which the host counteracts microbes that are constantly exposing the human body. These microbes rarely cause disease, due to the effective defense mechanisms of the host immune system. Although inflammation is essential for preventing infections, it can also damage the host. READ MORE

6. 4. Effects of bacterial toxins on calcium homeostasis in renal inflammation

   Author : Tomas Söderblom; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Calcium (Ca2+) is a highly versatile ion used for intra- and inter-cellular signalling in eukaryotic cells, and numerous cellular events are regulated by alteration of the intracellular Ca2+ concentration. We hypothesized that bacterial virulence factors may alter the Ca 2+ homeostasis in epithelial cells such that the innate immune response is affected. READ MORE

7. 5. Neutrophil interactions with Streptococcus pyogenes and Staphylococcus aureus

   Author : Julia Uhlmann; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Streptococcus pyogenes and Staphylococcus aureus are Gram-positive bacteria that share many features, including clinical presentations and pathogenic mechanisms, and yet, they still have unique properties. They both cause diseases ranging from uncomplicated infections to severe invasive diseases, such as sepsis and toxic shock syndrome, as well as severe tissue infections including necrotizing fasciitis and necrotizing pneumonia. READ MORE