Search for dissertations about: "porphyria cutanea tarda"

Found 1 swedish dissertation containing the words porphyria cutanea tarda.

2. 1. Clinical and experimental studies on HFE and other genes involved in iron homeostasis

   Author : Petra Holmström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Hereditary hemochromatosis; iron overload; HFE gene mutations; porphyria cutanea tarda; HFE gene; iron metabolism-related genes; iron homeostasis; liver; inflammation; and hepatocellular carcinoma;

   Abstract : In this thesis, the clinical significance of HFE mutations was further investigated, and the molecular mechanisms underlying the disturbed iron homeostasis during hemochromatosis, inflammation and hepatocellular carcinoma were studied in experimental models. Hereditary hemochromatosis (HH) is a prevalent autosomal recessive iron overload disorder caused by increased intestinal absorption and deposition of iron in vital organs, leading to organ damage. READ MORE