Search for dissertations about: "post modification"

Showing result 21 - 25 of 171 swedish dissertations containing the words post modification.

2. 21. Post-translational and therapy-induced modifications in rheumatoid arthritis

   Author : Dimitrios Makrygiannakis; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial proliferation and excessive mononuclear infiltration leading to destruction of bone and cartilage, with subsequent joint deformities and physical disability. Even though RA etiology is still unknown, autoantibody driven pathogenic mechanisms are considered to be important, with strong evidence for the pathogenic potentials of antibodies directed against citrullinated antigens. READ MORE

4. 22. Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing

   Author : Zheng Ge; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA elongation, is silent in most normal differentiated human cells due to the tight repression of its catalytic unit, telomerase reverse transcriptase (hTERT), whereas constitutive hTERT expression and telomerase activation are prerequisites for cellular immortalization/malignant transformation. As reconfiguration of chromatin acts like a master on/off switch, determining whether particular genes are active or inactive, the project was specifically designed to first elucidate molecular strategies that integrate diverse signalling pathways at the hTERT chromatin and consequently result in telomerase activation or repression in normal and malignant human cells. READ MORE

5. 23. Tailoring Surface Properties of Bio-Fibers via Atom Transfer Radical Polymerization

   Author : Josefina Lindqvist; Eva Malmström; Steven Rannard; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cellulose; bio-fiber; atom transfer radical polymerization; surface modification; grafting; polymer brushes; functional surfaces; superhydrophobic; stimuli-responsive; Polymer chemistry; Polymerkemi;

   Abstract : The potential use of renewable, bio-based polymers in high-technological applications has attracted great interest due to increased environmental concern. Cellulose is the most abundant biopolymer resource in the world, and it has great potential to be modified to suit new application areas. READ MORE

6. 24. High performing cast aluminium-silicon alloys

   Author : Martin Riestra; Salem Seifeddine; Ehsan Ghassemali; Jessica Elfsberg; Jönköping University; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aluminium cast alloys; melt quality; eutectic modification; grain refinement; microstructure; tensile properties;

   Abstract : The need to produce lighter components due to environmental aspects and the development of electrical vehicles represents an opportunity for cast aluminium-silicon alloys. With high specific strength, good castability, high corrosion resistance and recyclability, these alloys offer an attractive combination of properties as an alternative to steel, cast iron and titanium-based components in certain applications. READ MORE

7. 25. Exotic Ribosomal Enzymology

   Author : Josefine Liljeruhm; Anthony C. Forster; Christophe Danelon; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; rRNA modification; Methyltransferase; RlmM; RlmJ; D-amino acid; Unnatural amino acid; Chromoprotein; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Abstract : This thesis clarifies intriguing enzymology of the ribosome, the multiRNA/multiprotein complex that catalyzes protein synthesis (translation). The large ribosomal RNAs (23S and 16S rRNAs in E. coli) are post-transcriptionally modified by many specific modification enzymes, yet the functions of the modifications remain enigmatic. READ MORE