Search for dissertations about: "post synaptic density"

Showing result 1 - 5 of 11 swedish dissertations containing the words post synaptic density.

2. 1. Post-synaptic Density Disc Large Zo-1 (PDZ) Domains : From Folding and Binding to Drug Targeting

   Author : Celestine Chi; Per Jemth; Maria Selmer; Sarah Linse; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein-protein interaction; protein folding; and drug design; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Abstract : Understanding how proteins fold and bind is interesting since these processes are central to most biological activity. Protein folding and protein-protein interaction are by themselves very complex but using a good and robust system to study them could ease some of the hurdles. READ MORE

4. 2. Exploring the Role of the PDZ Domain in a Supramodule

   Author : Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

   Abstract : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. READ MORE

5. 3. Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics

   Author : Joachim Piguet; Horst Vogel; Ruud Hovius; Jerker Widengren; Antoine Triller; Switzerland Ecole Polytechnique Fédérale de Lausanne (EPFL); []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fluorescence; microscopy; plasma membrane; membrane proteins; membrane proteins diffusion; single-molecule imaging; single-molecule tracking; pentameric ligand-gated ion channels; nicotinic acetylcholine receptor; serotonin receptor; synapse; neuromuscular junction; post-synaptic scaffold; rapsyn; myopathies; fluorescent proteins; Förster resonance energy transfer; FRET imaging; protein-protein interactions; protein trafficking; photo-activatable proteins; Biological Physics; Biologisk fysik;

   Abstract : Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotinic acetylcholine is densely packed under the motor nerve termini. READ MORE

6. 4. Morphological and immunohistochemical studies on the organisation of sacral motoneurons

   Author : Vania Ramirez-Leon; Karolinska Institutet; Karolinska Institutet; []
   Keywords : spinal cord; dendrites; synaptic input; aging;

   Abstract : The aim of this thesis was to study pre- and postsynaptic elements during postnatal development and aging. Motoneurons from two adjacent sacral motor nuclei in the cat spinal cord were investigated: the motoneurons innervating intrinsic foot-sole muscles (dorsolateral motor nucleus; DLN) and the motoneurons innervating striated perineal muscles (Onufs nucleus, ventrolateral motor nucleus; VLN). READ MORE

7. 5. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis

   Author : Nenad Bogdanovic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Alzheimer s disease; CERAD; neurofibrillary tangles. neuritic plaques; apoE. synaptic proteins; rab3a; synaptophysin; synaptotagmin; GAP-43; neurogranin; neuronal degeneration; optical disector 1998;

   Abstract : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. READ MORE