Search for dissertations about: "post-translational modifications"

Showing result 6 - 10 of 118 swedish dissertations containing the words post-translational modifications.

  2. 6. Post-translational and therapy-induced modifications in rheumatoid arthritis

    Author : Dimitrios Makrygiannakis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial proliferation and excessive mononuclear infiltration leading to destruction of bone and cartilage, with subsequent joint deformities and physical disability. Even though RA etiology is still unknown, autoantibody driven pathogenic mechanisms are considered to be important, with strong evidence for the pathogenic potentials of antibodies directed against citrullinated antigens. READ MORE

  4. 7. Post-translational modifications of myelin oligodendrocyte glycoprotein in CNS autoimmunity

    Author : Andreas Warnecke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmunity towards components of the central nervous system (CNS) is a driving factor of nerve demyelination in Multiple Sclerosis (MS). The etiology of autoimmunity in MS pathogenesis remains elusive, but a combination of genetic predisposition and environmental triggers is theorized to initiate this complex disease. READ MORE

  5. 8. Post-translational modifications of XRCC1 by the protein kinase CK2

    Author : Cecilia Ström; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  6. 9. Post-translational modifications in mammary gland development and mammary tumor progression

    Author : Ting Zhuang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is one of the most common cancers in women. Estrogen receptor α (ERα) signaling and p53 signaling have important roles in breast cancer progression. Therefore, post-translational modifications of ERα and p53 play critical roles in breast cancer. READ MORE

  7. 10. Jack of all trades, master of none : the multifaceted nature of H3K36 methylation

    Author : Henrik Lindehell; Jan Larsson; Anders Byström; Peter B. Becker; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; H3K36; histone methylation; dosage compensation; chromosome-specific gene regulation; transposable elements; PIWI piRNA biosynthesis; Set2; Ash1; NSD; Histone 3.3; post-translational modifications; histone modifications; epigenetics; proximity ligation assay; Drosophila; Genetics; genetik; molekylärbiologi; Molecular Biology; Biopharmaceutics; biofarmaci;

    Abstract : Post-translational modifications of histones enable differential transcriptional control of the genome between cell types and developmental stages, and in response to environmental factors. The methylation of Histone 3 Lysine 36 (H3K36) is one the most complex and well-studied histone modifications and is known to be involved in a wide range of molecular processes. READ MORE