Search for dissertations about: "post-translational regulation"

Showing result 1 - 5 of 95 swedish dissertations containing the words post-translational regulation.

  2. 1. Systems biology techniques show high prevalence of post-translational regulation in the cyanobacterium Synechocystis PCC 6803

    Author : Jan Karlsen; Elton Paul Hudson; Martin Hagemann; KTH; []
    Keywords : systems biology; sustainable development; omics; ribosome profiling; RNA sequencing; proteomics; genetic engineering; bioproduction; cyanobacteria; gene regulation; metabolism; translational regulation; post-translational regulation; bioinformatics; Bioteknologi; Biotechnology;

    Abstract : Earth's climate has been upset by carbon dioxide (CO2) emissions from human activities and the use of fossil resources. To prevent catastrophic events on the environment and on civilizations, we urgently need to develop alternative solutions that utilize renewable resources. READ MORE

  4. 2. Regulation of TGF-β Signaling by Post-Translational Modifications

    Author : Peter Lönn; Aristidis Moustakas; Carl-Henrik Heldin; Petra Knaus; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. READ MORE

  5. 3. New fractionation tools targeting elusive post-translational modifications

    Author : Celina Wierzbicka; Malmö högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular imprinting; Molecular recognition; Phosphopeptides; Proteomics; Phosphotyrosine; Phosphohistidine;

    Abstract : Protein phosphorylation is a reversible post-translational modification (PTM)playing a central role in numerous biological events including disease pathogenesis.Thus, the analysis of phosphoproteome is crucial for understandingcellular regulation processes and can facilitate the development of new diagnosticand therapeutic tools. READ MORE

  6. 4. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology

    Author : Gabriel Antonio Heras Arribas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. READ MORE

  7. 5. Plant UDP-glucose Pyrophosphorylase : Function and Regulation

    Author : Meng Meng; Leszek Kleczkowski; Javier Pozueta-Romero; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; UDP-glucose pyrophosphorylase; carbohydrate metabolism; in vivo regulation; T-DNA knockout; heterologous expression; isozyme; mutagenesis; kinetic property; oligomerization; Plant physiology; Växtfysiologi;

    Abstract : UDP-glucose pyrophosphorylase (UGPase) is an important enzyme of carbohydrate metabolism in all living organisms. The main aim of this thesis was to investigate the function and regulation of plant UGP genes as well as the UGPase proteins. READ MORE