Search for dissertations about: "postnatal β cell maturation."

Found 3 swedish dissertations containing the words postnatal β cell maturation..

  2. 1. On macrophage contributions to tissue homeostasis : New insights on pancreas development and healing of ischemic injury

    Author : Carmen Herrera Hidalgo; Mia Phillipson; Andrés Hidalgo; Uppsala universitet; []
    Keywords : macrophages; islets of Langerhans; β cell function; postnatal β cell maturation; hindlimb ischemia; blood flow regulation; mural cells; vessel pruning; diabetes mellitus; ischemic diseases;

    Abstract : Besides providing host defence against innumerable threats, macrophages display additional key functions for preservation of tissue homeostasis. This thesis includes four studies that explore novel macrophage functions in both the development of islets of Langerhans and healing of ischemic injury in mice. READ MORE

  4. 2. Macrophages and neutrophils in tissue homeostasis and recovery from ischemic injury

    Author : Kristel Parv; Mia Phillipson; Gustaf Christoffersson; Per-Ola Carlsson; Stephen Jenkins; Uppsala universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; neutrophils; hindlimb ischemia; ischemic disease; mural cells; diabetes mellitus; postnatal β cell maturation.;

    Abstract : Neutrophils and macrophages have functions beyond protection against pathogens. The overall aim of the work presented in this thesis was to identify novel tasks for these innate immune cells in maintaining homeostasis. READ MORE

  5. 3. Fishing for small molecules to treat diabetes, from a beta cell perspective

    Author : Lipeng Ren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Maintenance of glucose homeostasis necessitates a precise control of insulin secretion. Pancreatic β cells sense fluctuation of blood glucose and secret insulin in response. However, functional β cell mass is decreased in diabetes. Here, to recover functional β cell mass, we use zebrafish as a model to perform in vivo drug discovery. READ MORE