Search for dissertations about: "potassium channels"

Showing result 1 - 5 of 66 swedish dissertations containing the words potassium channels.

2. 1. The interplay of ions in the stimulation of the pancreatic -cell

   Author : Michael Eberhardson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; pancreatic β-cells; cytoplasmic calcium; oscillations; glucose; tetrodotoxin; tolbutamide; veratridine; tetraethylammonium; quinine; cesium; H2DIDS; furosemide; transients; microfluorometry; fura-2; MQAE; calcium channels; potassium channels; sodium channels; chloride channels; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Glucose stimulation of insulin release is mediated by depolarisation of the pancreatic β-cells with accompanying entry of Ca2+ through voltage-dependent channels. An important feature of the glucose-induced depolarisation is its rhythmicity causing oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), which trigger pulsatile release of insulin. READ MORE

4. 2. A-type Potassium Channels in Dendritic Integration : Role in Epileptogenesis

   Author : Jenny Tigerholm; Erik Fransén; Fredrik Elinder; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; epileptogenesis; fast ripples; synchronicity; dendritic potentials; transient A–type potassium current; KV 4.2; Computer and systems science; Data- och systemvetenskap;

   Abstract : During cognitive tasks, synchronicity of neural activity varies and is correlated with performance. However, there may be an upper limit to normal synchronised activity – specifically, epileptogenic activity is characterized byexcess spiking at high synchronicity. READ MORE

5. 3. Role of potassium channels in regulating neuronal activity

   Author : Göran Klement; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

   Abstract : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. READ MORE

6. 4. Pulsatile insulin release from single islets of Langerhans

   Author : Johanna Westerlund; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islets of Langerhans; insulin; ELISA; cytoplasmic calcium; oscillations; type 2 diabetes; glucose; diazoxide; potassium; tolbutamide; DNP; antimycin A; iodoacetamide; microfluorometry; fura-2; KATP channels; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. READ MORE

7. 5. Oscillatory Ca2+ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine

   Author : Meftun Ahmed; Per Lindström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; pancreatic β-cells; islets of Langerhans; glucose; Ca2 oscillations; Ca2 transients; potassium; ryanodine; caffeine; glucagon; cAMP; inositol 1; 4; 5-trisphosphate; fura-2; glycine; alanine; arginine; Ca2 channels; rats; lean mice; ob ob mice; leptin; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Oscillations in cytoplasmic Ca2+ concentration ([Ca2+]i) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca2+] i. READ MORE