Search for dissertations about: "ppargc1a"

Found 5 swedish dissertations containing the word ppargc1a.

  1. 1. Genes predisposing to type 2 diabetes and cardiovascular mortality

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Jenny Fredriksson; Lunds universitet.; Lund University.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; APM1; PPARG; PPARGC1A; survival abalysis; Medicin människa och djur ; Medicine human and vertebrates ; Type 2 Diabetes; cardiovascular mortality; glycogen synthase; adiponectin; GYS1;

    Abstract : Popular Abstract in Swedish Typ 2 diabetes är en sjukdom där dels bukspottkörtelns förmåga att producera hormonet insulin och dels kroppens förmåga att svara på insulin (insulinkänslighet) är nedsatt. Eftersom insulin behövs för att ta upp socker (glukos) från blodet i organ som muskel och fett, är glukoskoncentrationen i blodet förhöjd hos typ 2 diabetiker. READ MORE

  2. 2. Gene x lifestyle interactions in type 2 diabetes mellitus and related traits

    University dissertation from Umeå : Umeå University

    Author : Ema C Brito; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene x environment interaction; gene x lifestyle interaction; physical activity; type 2 diabetes; European Youth Heart Study; Malmö Preventive Project; Prevalence and Prediction and Prevention of Diabetes in Botnia; PPARGC1A; CDKN2A B; HNF1B; TCF7L2; FTO; MEDICINE Social medicine Public health medicine research areas Epidemiology; MEDICIN Socialmedicin Folkhälsomedicinska forskningsområden Epidemiologi; Epidemiology; epidemiologi; genetik; Genetics;

    Abstract :  Background: Type 2 diabetes is thought to result from interactions between genetic and lifestyle factors, but few robust examples exist. The overarching aim of this thesis was to discover such interactions by studying cohorts of white youth and adults from northern Europe in which physical activity, genotypes, and diabetes-related traits or diabetes incidence had been ascertained. READ MORE

  3. 3. Adipose tissue gene expression & candidate genes for obesity

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Lovisa Johansson; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; Obesity; Adipose tissue; Adiponutrin; PNPLA; PPARGC1A; Gene expression; Case-control association study; Microarray; Genotyping; Population-based study;

    Abstract : Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene approaches with focus on the adipose tissue. READ MORE

  4. 4. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

    University dissertation from Tina Rönn, Lund University

    Author : Tina Rönn; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

    Abstract : Popular Abstract in Swedish Diabetes är en grupp sjukdomar som alla kännetecknas av en förhöjd nivå av sockerarten glukos i blodet. Antalet individer som drabbas av diabetes ökar hela tiden, en utveckling som ses över hela världen. Bara i Sverige har drygt 5% av befolkningen diagnosen diabetes, motsvarande 484. READ MORE

  5. 5. Characterisation of human adipose tissue : ceramide metabolism, depot differences and evaluation of dysfunctionality

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Joanna Gertow; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Normal adipose tissue function is necessary for maintaining proper energy balance, as both excess and absence of this tissue lead to metabolic disturbances, such as insulin resistance. Adipose tissue can be dysfunctional in many ways, including disturbances in adipocyte size, lipolysis rate, adipokine secretion, inflammation, fibrosis or oxidative stress. READ MORE