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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

2. 1. Genes predisposing to type 2 diabetes and cardiovascular mortality

   Author : Jenny Fredriksson; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; APM1; PPARG; PPARGC1A; survival abalysis; Medicin människa och djur ; Medicine human and vertebrates ; Type 2 Diabetes; cardiovascular mortality; glycogen synthase; adiponectin; GYS1;

   Abstract : Cardiovascular complications are frequent in type 2 diabetes (T2D) and cardiovascular death is the most common cause of death for these individuals. A region on chromosome 19 (19q13) has been indicated by several genome scans as a susceptibility locus for T2D or components of the metabolic syndrome (MetS). READ MORE

4. 2. Gene x lifestyle interactions in type 2 diabetes mellitus and related traits

   Author : Ema C Brito; Paul Franks; Aline Meirhaeghe; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene x environment interaction; gene x lifestyle interaction; physical activity; type 2 diabetes; European Youth Heart Study; Malmö Preventive Project; Prevalence and Prediction and Prevention of Diabetes in Botnia; PPARGC1A; CDKN2A B; HNF1B; TCF7L2; FTO; Epidemiology; Epidemiologi; epidemiologi; Epidemiology; genetik; Genetics;

   Abstract :   Background: Type 2 diabetes is thought to result from interactions between genetic and lifestyle factors, but few robust examples exist. The overarching aim of this thesis was to discover such interactions by studying cohorts of white youth and adults from northern Europe in which physical activity, genotypes, and diabetes-related traits or diabetes incidence had been ascertained. READ MORE

5. 3. Adipose tissue gene expression & candidate genes for obesity

   Author : Lovisa Johansson; Diabetes - klinisk obesitasforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; Obesity; Adipose tissue; Adiponutrin; PNPLA; PPARGC1A; Gene expression; Case-control association study; Microarray; Genotyping; Population-based study;

   Abstract : Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene approaches with focus on the adipose tissue. READ MORE

6. 4. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes

   Author : Mi Huang; Genetisk och molekylär epidemiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Obesity; Type 2 diabetes; CRISPR Cas9; precision medicine; adipocytes; functional genomics;

   Abstract : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. READ MORE

7. 5. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

   Author : Tina Rönn; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

   Abstract : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. READ MORE