Search for dissertations about: "pre-RC"

Found 1 swedish dissertation containing the word pre-RC.

2. 1. The role of cyclin E in cell cycle regulation and genomic instability

   Author : Susanna Ekholm-Reed; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Cyclin E; cell cycle; Restriction point; pre-RC; Mcm proteins; DNA replication; tumorigenesis; proteolysis; hCdc4;

   Abstract : Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human cancer, cyclin E is overexpressed and in some cases its expression becomes deregulated, a phenomenon generally associated with poor prognosis. READ MORE