Search for dissertations about: "pre-clinical trial"

Showing result 1 - 5 of 6 swedish dissertations containing the words pre-clinical trial.

  1. 1. Development and application of a patient-derived xenograft platform to test anticancer agents

    University dissertation from Gothenburg : University of Gothenburg

    Author : Berglind Einarsdottir; Göteborgs universitet.; Gothenburg University.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malignant melanoma; patient-derived xenografts; MTH1; pre-clinical trial; Karonudib;

    Abstract : Malignant melanoma is the most aggressive form of skin cancer and incidence rates are on the rise. Despite recent improvements in treatment options, the disease still remains lethal. Which calls for expedited solutions. READ MORE

  2. 2. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Robin J. Svensson; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. READ MORE

  3. 3. Virtual patients for education, assessment and research : A webbased approach

    University dissertation from Stockholm : Karolinska Institutet, Department of Learning, Informatics, Management and Ethics (Lime)

    Author : Nabil Zary; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virtual patients; computer simulation; patient simulation; computer-based learning; computer-assisted instruction; computer-managed instruction; problem solving; clinical reasoning; clinical knowledge; computer assisted cases; interactive case-based learning.;

    Abstract : Virtual simulations of patient encounters have been an increasingly important complement in the development of healthcare competence. Virtual patients (VPs) are interactive computer programs that simulate real-life clinical scenarios, provide an effective way for healthcare professionals and students to not only learn about a wide range of clinical topics, but also to practice in a virtual and therefore safe environment. READ MORE

  4. 4. Model-based Approaches to Diffuse Optical Imaging and Dosimetry

    University dissertation from Division of Atomic Physics, Department of Physics, Faculty of Engineering, LTH, Lund University

    Author : Johan Axelsson; Lund University.; Lunds universitet.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; photodynamic therapy; diffuse light propagation; fluorescence; imaging; dosimetry; inverse problem;

    Abstract : The work within this thesis investigates Photodynamic therapy and Fluorescence imaging for therapeutics and visualization of deeply embedded lesions. Photodynamic therapy (PDT) is a cancer treatment modality that can eradicate tumors when light, a photosensible drug and oxygen are present. READ MORE

  5. 5. Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Azita Monazzam; Uppsala universitet.; [2007]
    Keywords : Oncology; Positron Emission Tomography; Multicellular Tumour Spheroid; Translational Research; Onkologi;

    Abstract : Positron Emission Tomography (PET) has gained an important roll in clinical for diagnosis, staging and prognosis of a range of cancer types. Utilization of PET for monitoring and evaluation of cancer treatment is an attractive but almost new concept. The proper choice of PET-tracer as a biomarker for treatment follow-up is crucial. READ MORE