Search for dissertations about: "pre-clinical"

Showing result 1 - 5 of 86 swedish dissertations containing the word pre-clinical.

  1. 1. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design Pre-Clinical and Clinical Study Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Charles Ernest II; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). READ MORE

  2. 2. Change and variability in cognitive performance in old age. Effects of retest, terminal decline, and pre-clinical dementia

    University dissertation from Göteborg : University of Gothenburg

    Author : Valgeir Thorvaldsson; Göteborgs universitet.; Gothenburg University.; [2008]
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Aging; cognition; longitudinal; retest effects; terminal decline; pre-clinical;

    Abstract : The focus of the presented studies was to provide population estimates of change and variability in cognitive performance in old age. Data was drawn from the Gerontological and Geriatric Population Studies in Gothenburg, Sweden (H70). In study I retest effects were evaluated on level of performance in five cognitive abilities. READ MORE

  3. 3. Pre-clinical investigations of a dopamine autoreceptor agonist : selective stimulators of central dopamine and serotonin receptors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Seth-Olov Thorberg; Uppsala universitet.; [1988]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 4. Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery SPR-biosensor Aided Interaction Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Winquist; Uppsala universitet.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

    Abstract : The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance. READ MORE

  5. 5. On component integration in total hip arthroplasty. Pre-clinical evaluation

    University dissertation from Göteborg

    Author : Warren Macdonald; Göteborgs universitet.; Gothenburg University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Total hip arthroplasty; orthopaedic implants; implant design; biomechanical testing; in vitro evaluation; titanium; zirconia; polyethylene; surgical accuracy;

    Abstract : .... READ MORE