Search for dissertations about: "pre-clinical"

Showing result 16 - 20 of 116 swedish dissertations containing the word pre-clinical.

  2. 16. The significance of low-grade inflammation in the gastrointestinal tract

    Author : David Lundgren; Pontus Karling; Mårten Werner; Klas Sjöberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Low-grade inflammation; gastrointestinal tract; faecal calprotectin; inflammatory bowel disease; Ulcerative colitis; irritable bowel syndrome; biomarkers; colonoscopy; proton pump inhibitors; albumin; C-reactive protein; Medicine; medicin;

    Abstract : BackgroundGastrointestinal (GI) symptoms are commonly reported in a normal population. Mostly, the symptoms are of benign cause but occasionally the symptoms can be signs of a more harmful disease. In general, it is difficult to distinguish whether the reported symptoms are caused by a benign (functional) or organic (i.e. READ MORE

  4. 17. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients

    Author : Carl Roos; Hans Lennernäs; Erik Sjögren; Martin Brandl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

    Abstract : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. READ MORE

  5. 18. Altering Radiation Response with Time, Volume and Fractionation

    Author : Gabriel Adrian; LUCC: Lunds universitets cancercentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Radioresistance, the failure to achieve a desired outcome, is an obstacle in clinical radiotherapy. In this thesis we investigate factors affecting radioresistance and strategies to overcome it, both with established clinical approaches and by using novel pre-clinical discoveries. READ MORE

  6. 19. Drug-resistance in M. tuberculosis and the characterisation of a new anti-tuberculosis drug-candidate

    Author : Emma Huitric; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The occurrence of multidrug-resistant (MDR) tuberculosis (TB) has been increasing at alarming levels globally, and the spread of extensively drug-resistant (XDR) M. tuberculosis is threatening the control of tuberculosis. READ MORE

  7. 20. A mouse model for direct evaluation of cholera vaccines

    Author : Erik Nygren; Göteborgs universitet; []
    Keywords : Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Abstract : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). READ MORE