Search for dissertations about: "preclinical"

Showing result 1 - 5 of 252 swedish dissertations containing the word preclinical.

  1. 1. EGFR and HER2 Targeting for Radionuclide-Based Imaging and Therapy : Preclinical Studies

    Author : Erika Nordberg; Bengt Glimelius; Jörgen Carlsson; Lars Gedda; Bo Stenerlöw; Vladimir Tolmachev; Peter Bernhardt; Uppsala universitet; []
    Keywords : Biomedicine; EGFR; HER2; affibody molecule; tumour targeting; 125I; 111In; Biomedicin;

    Abstract : The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting the surrounding tissue. One promising approach is to use radiolabelled molecules to target receptors that are overexpressed in cancer cells. READ MORE

  2. 2. Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies

    Author : Mikael Persson; Per-Uno Malmström; Vladimir Tolmachev; Jörgen Carlsson; Marion De Jong; Uppsala universitet; []
    Keywords : Molecular medicine; Neoplasm Antibodies; Targeted Radiotherapy; Radionuclide Imaging; Molekylärmedicin;

    Abstract : Targeted radionuclide therapy (TRT) holds great promise for the treatment of cancer. In TRT, radioactive nuclides are delivered specifically to tumours by molecules that recognise and bind to structures overexpressed by, or specific to, cancer cells. READ MORE

  3. 3. Radioimmunodiagnosis of Head and Neck Squamous Cell Carcinomas : Preclinical Studies

    Author : Karl Sandström; Matti Anniko; Marika Nestor; Hans Lundqvist; Göran Laurell; Uppsala universitet; []
    Keywords : Head and neck squamos cell carcinoma; radioimmunotargeting; radioimmunodiagnosis; MEDICINE; MEDICIN;

    Abstract : Despite improvements in treatment, the prognosis for patients with advanced head and neck squamous cell carcinomas (HNSCC) has only improved to a minor degree. To raise the success rate and minimize morbidity further developments in diagnostics are highly desired. Radioimmunodiagnosis could offer a more specific and sensitive diagnostic method. READ MORE

  4. 4. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies

    Author : Ann-Charlott Steffen; Jörgen Carlsson; Vladimir Tolmachev; Lars Gedda; Ragnar Hultborn; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; HER-2; affibody; 211At; tumor targeting; targeted radiotherapy; molecular imaging; Biomedicin; Microbiology; Mikrobiologi;

    Abstract : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. READ MORE

  5. 5. Tumour Targeting Using Radiolabelled EGF Conjugates : Preclinical Studies

    Author : Åsa Liljegren Sundberg; Jörgen Carlsson; Lars Gedda; Vladimir Tolmachev; Erik Blomquist; Gregory P. Adams; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; Radiation biology; Strålningsbiologi;

    Abstract : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. READ MORE