Search for dissertations about: "preclinical"

Showing result 16 - 20 of 313 swedish dissertations containing the word preclinical.

  2. 16. Targeted Therapy of Colorectal Cancer : Preclinical Evaluation of a Radiolabelled Antibody

    Author : Ylva Almqvist; Anders Sundin; Vladimir Tolmachev; Hans Lundqvist; Matthew K Robinson; Uppsala universitet; []
    Keywords : Molecular medicine; tumour targeting; antibody; A33; radionuclide; colorectal cancer; therapy; Molekylärmedicin;

    Abstract : Targeted radiotherapy (TRT) of cancer is a promising approach that enables selective treatment of tumour cells, while sparing normal tissue. The humanized monoclonal antibody A33 (huA33) is a potential targeting agent for TRT of colorectal cancer, since its antigen is expressed in more than 95 % of all colorectal carcinomas. READ MORE

  4. 17. Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study

    Author : Pei Pei Chau; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcoholism; Acamprosate; Glycine receptor; Preclinical study; Dopamine; Ethanol;

    Abstract : Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) and nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system, as two potentially important targets for the development of new medication to treat alcohol dependence. READ MORE

  5. 18. Preclinical X-ray imaging beyond attenuation contrast

    Author : Kian Shaker; Hans Hertz; Anna Burvall; Bert Müller; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysik; Physics; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Abstract : Medical imaging is a cornerstone of modern clinical practice. Here, X-ray imaging is the given choice for rapid morphological imaging with excellent spatial resolution, albeit with sensitivity often insufficient for resolving subtle pathological changes to soft tissues. READ MORE

  6. 19. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

    Author : Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

    Abstract : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. READ MORE

  7. 20. Preclinical Studies for Cryoprevention of Oral Mucositis

    Author : Java Walladbegi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Animal model; Chemotherapy; Cryotherapy; Hematopoietic stem cell transplantation; Ice chips; Intraoral cooling device; Microcirculation; Randomized controlled trial; Tissue-engineered oral mucosa; Tissue oxygen saturation; Tolerability;

    Abstract : Oral mucositis (OM) is a debilitating adverse effect, with a prevalence of up to 80% in patients with cancer who are conditioned with high-dose chemotherapy prior to hematopoietic stem cell transplantation. In its mildest form, OM is characterized by erythema. However, as it worsens, it can give rise to painful ulcerations in the oral mucosa. READ MORE