Search for dissertations about: "preclinical"

Showing result 6 - 10 of 313 swedish dissertations containing the word preclinical.

2. 6. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs

   Author : Tove Selvin; Mårten Fryknäs; Rolf Larsson; Claes Andersson; Malin Jarvius; Brinton Seashore-Ludlow; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; anti-cancer drugs; preclinical modeling; drug screening; repurposing;

   Abstract : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. READ MORE

4. 7. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

   Author : Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

   Abstract : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. READ MORE

5. 8. Molecular Radionuclide Imaging Using Site-specifically Labelled Recombinant Affibody Molecules : Preparation and Preclinical Evaluation

   Author : Sara Ahlgren; Vladimir Tolmachev; Anna Orlova; Göran Hedenstierna; Joachim Feldwisch; Raymond Reilly; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular radionuclide imaging; Affibody molecules; HER2; cancer detection; radiolabelling; technetium; indium; cobalt; SPECT; PET; Oncology; Onkologi; Diagnostic radiology; Diagnostisk radiologi; Radiation biology; Strålningsbiologi; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Medicinsk vetenskap; Medical Science;

   Abstract : Radionuclide molecular imaging is an emerging multidisciplinary technique that is used in modern medicine to visualise diseases at cellular and molecular levels. This thesis is based on five papers (I-V) and focuses on the development of site-specific radiolabelled recombinant anti-HER2 Affibody molecules and preclinical evaluations in vitro and in vivo of the labelled conjugates. READ MORE

6. 9. Preclinical studies of roscovitine

   Author : Marina Vita; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

   Abstract : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. READ MORE

7. 10. Anticancer Activity of Melflufen : Preclinical Studies of a Novel Peptidase-Potentiated Alkylator

   Author : Sara Strese; Joachim Gullbo; Rolf Larsson; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancertherapy; preclinical studies; melflufen; aminopeptidase-potentiated; cancer; angiogenesis; Klinisk farmakologi; Clinical Pharmacology;

   Abstract : Melflufen (melphalan flufenamide, chemical name L-melphalanyl-p-L-fluorophenylalanine ethyl ester hydrochloride, previously called J1) is a derivative of the classical alkylating agent melphalan. Melflufen is potentiated by hydrolytic cleavage by aminopeptidase N (APN), leading to high intracellular concentrations of alkylating moieties and subsequent cell death. READ MORE