Search for dissertations about: "preconcentration"

Showing result 1 - 5 of 20 swedish dissertations containing the word preconcentration.

  2. 1. Sample preconcentration in open microchannels : Combinations with MALDI and nano-ESI mass spectrometry and computer simulations

    Author : Saara Mikkonen; Åsa Emmer; Leopold Ilag; Jenny Ottosson Takanen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Preconcentration; open microchannel; microchip; MALDI; electrospray ionization; nanoelectrospray; mass spectrometry; computer simulation;

    Abstract : In this thesis a novel concept for preconcentration of biomolecules in open microchannels is presented. The preconcentration is based on electromigration of charged analytes, and detection is performed with matrix-assisted laser desorption/ionization (MALDI) or nano-electrospray ionization (nESI) mass spectrometry (MS). READ MORE

  4. 2. Electrophoretic focusing in microchannels combined with mass spectrometry : Applications on amyloid beta peptides

    Author : Saara Mikkonen; Åsa Emmer; Johan Jacksén; Tapio Kotiaho; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

    Abstract : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. READ MORE

  5. 3. Inductively Coupled Plasma Atomic Emission Spectrometry : Exploring the Limits of Different Sample Preparation Strategies

    Author : Barbro Kollander; Jean Pettersson; Marit Andersson; Jonas Bergquist; Grethe Wibetoe; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; multi element analysis; trace element; ICP-AES; inductively coupled plasma atomic emission spectromtery; water analysis; liver analysis; non digested samples; medical samples; biological samples; samples from biopsies and autopsies; mice organ; fast analysis; internal standard; preconcentration; matrix elimination; Cu; Zn; Mn; Co; Pb; Cd; Mg; Ca; Fe; Ni; Cr; S; P; K; Al; Analytical chemistry; Analytisk kemi; Analytical Chemistry; Analytisk kemi;

    Abstract : This thesis describes two different sample preparation strategies for inductively coupled plasma atomic emission spectrometry (ICP-AES), and their ability regarding multi element quantification in complex samples. Sensitivity, repeatability, reproducibility and accuracy were investigated. READ MORE

  6. 4. Development and Investigations of Novel Sample Preparation Techniques : Electrochemical Extraction and Evaluation of Miniaturized Analytical Devices Coupled to Mass Spectrometry

    Author : Gustav Liljegren; Leif Nyholm; Jean Pettersson; Per Sjöberg; Ari Ivaska; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Electrochemical extraction; Solid-phase microextraction; Solid-phase extraction; Microchip; Mass spectrometry; Polypyrrole; Pressurized-fluid extraction; Preconcentration; Electrospray ionization; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Different sample preparation steps prior to a detection method are often essential in analytical chemistry. In this thesis, both static extractions and on-line coupled solid-phase extractions have been studied in combination with different detection techniques. READ MORE

  7. 5. Sensitivity and selectivity studies in capillary electrophoresis

    Author : Maria Petersson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptides; dansyl amino acids; imaging detection; cyclodextrins; enantiomer separation; acoustic levitation; solid-phase extraction; preconcentration; capillary electrophoresis; micellar electrokinetic chromatography; drugs; Analytical chemistry; Analytisk kemi;

    Abstract : Capillary electrophoresis is characterised by high separation efficiency, applicability to a wide range of compounds, small sample and solvent consumption and simple instrumentation. To improve sensitivity using on-line absorbance detectors, which are hampered by the short optical path length, sample volumes in the microlitre range were concentrated to nanolitre volumes either off-line or on-line. READ MORE