Search for dissertations about: "prediabetes"

Showing result 1 - 5 of 16 swedish dissertations containing the word prediabetes.

  1. 1. The impact of diabetes on cognitive aging and dementia

    University dissertation from Stockholm : Karolinska Institutet, Dept of Neurobiology, Care Sciences and Society

    Author : Anna Marseglia; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prediabetes;

    Abstract : The impact of prediabetes and diabetes on different stages of cognitive function during aging remains unclear. This thesis aimed to investigate the impact of prediabetes and of diabetes on cognitive aging—from cognitive deficits, through cognitive decline, to dementia—, explore underlying cerebral mechanisms and identify factors that may protect older adults with diabetes from dementia. READ MORE

  2. 2. Pharmacometrics Modelling in Type 2 Diabetes Mellitus Implications on Study Design and Diabetes Disease Progression

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Siti Maisharah Sheikh Ghadzi; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometric; type 2 diabetes mellitus; impaired glucose tolerance; prediabetes; anti-diabetes drug development; insulin; glucose; natural diabetes disease progression; lifestyle intervention; short-term provocation; long-term effect; glucose homeostasis; glucose and insulin regulation; weight; dropout; Pharmaceutical Science; Farmaceutisk vetenskap; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE

  3. 3. Metabolic and endocrine effects of SGLT2 inhibition

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Per Lundkvist; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SGLT2 inhibition; GLP-1 receptor agonism; DPP4 inhibition; NAFLD; prediabetes; type 2 diabetes; obesity; metabolic syndrome; glucagon.; Medicinsk vetenskap; Medical Science;

    Abstract : Obesity and type 2 diabetes (T2D) are two growing global health problems with similar comorbidity profiles. SGLT2 inhibitors (SGLT2i) improve blood glucose control and can relieve both T2D and obesity, as well as their associated health problems such as hypertension, kidney failure, and cardiovascular disease. READ MORE

  4. 4. Lifestyle and glycaemic control before and after the onset of type 2 diabetes

    University dissertation from Lund University, Faculty of Medicine

    Author : Robert Koivula; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Prediabetes; Obesity; Beta-cell Function; Insulin Sensitivity; Physical Activity; Exercise; Diet; Lifestyle; Ectopic Fat; Genetic Epidemiology; Genetic Risk; Biomarker; Precision Medicine;

    Abstract : Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic dysregulation and eventual T2D. READ MORE

  5. 5. Support for physical activity in individuals with prediabetes and type 2 diabetes in primary care - the Sophia Step Study

    University dissertation from Stockholm : Karolinska Institutet

    Author : Jenny Rossen; Karolinska Institutet.; Karolinska Institutet.; Sophiahemmet Högskola.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : A health promoting-care approach includes supporting the individual to increase control over and to improve his or her health to obtain the best possible wellbeing and quality of life. In prediabetes and type 2 diabetes regular physical activity is of pronounced importance for preventing complications and premature death as well as to enhance quality of life. READ MORE