Search for dissertations about: "predictions in tissue"

Showing result 1 - 5 of 41 swedish dissertations containing the words predictions in tissue.

2. 1. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo

   Author : Anna Vildhede; Per Artursson; Maria Karlgren; Maria Kjellsson; Ulf Norinder; Kim Brouwer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OATP1B1; OATP1B3; OATP2B1; NTCP; drug transporters; human hepatocytes; atorvastatin; pitavastatin; proteomics; sandwich-cultured human hepatocytes; SCHH; mechanistic modeling; in vitro-in vivo extrapolation; transport inhibition; hepatic uptake; hepatocyte isolation; transporter contribution; Biopharmaceutics; Biofarmaci;

   Abstract : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. READ MORE

4. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

   Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

   Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

5. 3. Drug absorption in the lungs : studies in the isolated perfused rat lung model combined with physiologically based biopharmaceutics modelling

   Author : Johanna Eriksson; Hans Lennernäs; Erik Sjögren; Helena Thörn; Ben Forbes; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pulmonary drug absorption; physiologically based biopharmaceutics modeling; pulmonary drug delivery; Biofarmaci; Biopharmaceutics;

   Abstract : Pulmonary delivery of drugs is the preferred route of administration for treatment of local lung diseases like asthma and chronic obstructive pulmonary disease. Recently, there has also been increased interest in systemic delivery of drugs via the lungs to avoid problems with low and/or variable gastrointestinal absorption, and as a needle-free alternative for drugs that cannot be ingested. READ MORE

6. 4. Transverse anisotropy in softwoods : Modelling and experiments

   Author : Carl S. Modén; Lars Berglund; Lennart Salmén; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Softwood; Cellular solid; Anisotropy; Deformation mechanisms; Materials science; Teknisk materialvetenskap;

   Abstract : Transverse anisotropy is an important phenomenon of practical and scientific interest. Although the presence of ray tissue explains the high radial modulus in many hardwoods, experimental data in the literature shows that this is not the case for pine. READ MORE

7. 5. The oesophageal mucosa in reflux disease - endoscopic appearance and tissue structure

   Author : Anders Edebo; Göteborgs universitet; []
   Keywords : oesophagus; reflux; angiotensin; epithelium; endoscopy;

   Abstract : Gastro-oesophageal reflux disease (GORD) is very common in especially the western world. The cardinal symptoms are heartburn or regurgitations and are caused by the reflux of noxious compounds from the stomach/duodenum to the oesophagus. READ MORE