Search for dissertations about: "predictive biomarker signatures"

Found 5 swedish dissertations containing the words predictive biomarker signatures.

  2. 1. GARD – Genomic Allergen Rapid Detection : From Biomarker Discovery towards a State-of-the-art Testing Platform for Chemical Sensitizers

    Author : Andy Forreryd; Institutionen för immunteknologi; []
    Keywords : In vitro assay; skin sensitization; respiratory sensitization; predictive biomarker signatures; in vitro test; hudsensibilisering; luftvägssensibilisering; biomarkörsignaturer;

    Abstract : Chemical hypersensitivity reactions induced in the skin or in the respiratory tract are important health concerns and develops following repeated exposure to certain chemicals, termed sensitizers. To prevent such hazardous compounds from entering the consumer market, legal frameworks within EU require chemicals to be tested for their capacity to induce hypersensitivity. READ MORE

  4. 2. Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer : biology and clinical implications

    Author : Ioannis Zerdes; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling axis, immune-related gene signatures and immune cell subpopulations needs to be fully elucidated while the identification of prognostic and predictive biomarkers in BC is of utmost importance. READ MORE

  5. 3. Prediction-driven decision rules, RCT design and survival analysis

    Author : Adam Brand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Predictions are becoming more and more a part of our lives, and they are becoming increasingly useful in medical science as the science evolves. Increased understanding of disease and its treatments allows us to use predictions based on predictive biomarker signatures to optimize treatment outcomes for increasingly granular subject groups. READ MORE

  6. 4. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform

    Author : Mattias Brofelth; Institutionen för immunteknologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affinity proteomics; Antibody microarrays; scFv; Biomarkers; MIAS;

    Abstract : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. READ MORE

  7. 5. Spatial immune analyses in clinical cancer tissue

    Author : Max Backman; Patrick Micke; Fredrik Pontén; Johan Botling; Kurt Schalper; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune landscape; non-small cell lung cancer; immune cells; multiplex immunofluorescence; spatial analysis; Medicinsk vetenskap; Medical Science;

    Abstract : Cancer is a leading cause of premature death and lung cancer is the deadliest cancer type, with non-small cell lung cancer (NSCLC) representing 85% of lung cancer cases. Despite promising development in cancer treatment in recent decades, overall prognosis is poor. READ MORE