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Showing result 1 - 5 of 12 swedish dissertations matching the above criteria.

2. 1. Mapping the consequenses of physical exercise and nutrition on human health : A predictive metabolomics approach

   Author : Elin Chorell; Henrik Antti; Lorraine Brennan; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; physical exercise; cardiorespiratory fitness nutrition; high protein and fat diet; Lactobacillus F19; probiotics; GC-MS; plasma; chemometrics; multivariate analysis statistical experimental design; design of experiments; Chemistry; Kemi; Systems Analysis; systemanalys; näringslära; Nutrition; molecular medicine medical sciences ; molekylär medicin medicinska vetenskaper ;

   Abstract : Human health is a complex and wide-ranging subject far beyond nutrition and physical exercise. Still, these factors have a huge impact on global health by their ability to prevent diseases and thus promote health. READ MORE

4. 2. Multivariate profiling of metabolites in human disease : Method evaluation and application to prostate cancer

   Author : Elin Thysell; Henrik Antti; Janne Lehtiö; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolite profiling; metabolomics; predictive metabolomics; mass spectrometry; GC-MS; biomarkers; chemometrics; design of experiments; multivariate data analysis; prostate cancer; bone metastases; plasma; biologisk kemi; biological chemistry;

   Abstract : There is an ever increasing need of new technologies for identification of molecular markers for early diagnosis of fatal diseases to allow efficient treatment. In addition, there is great value in finding patterns of metabolites, proteins or genes altered in relation to specific disease conditions to gain a deeper understanding of the underlying mechanisms of disease development. READ MORE

5. 3. GC-MS based metabolomics – Development of a next generation GC-MS method and its application to nutrition and biomarker research

   Author : Otto Savolainen; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gas chromatography; nutrition; biomarkers; metabolomics; mass spectrometry; type 2 diabetes;

   Abstract : Metabolomics, the measurement of a broad range of small molecules in a sample, is maturing as a field in analytical chemistry and becoming a standard research tool in biological sciences for helping to generate a wider understanding of the complex biological mechanisms behind, for example, development of disease and effects of diet on health. Metabolomics analysis is generally divided into either targeted or untargeted metabolomics. READ MORE

6. 4. Multivariate processing and modelling of hyphenated metabolite data

   Author : Pär Jonsson; Michael Sjöström; Royston Goodacre; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Curve Resolution; GC MS; LC MS; Metabolomics; Metabonomics; Multivariate Analysis and Multivariate Curve Resolution.; Organic chemistry; Organisk kemi;

   Abstract : One trend in the ‘omics’ sciences is the generation of increasing amounts of data, describing complex biological samples. To cope with this and facilitate progress towards reliable diagnostic tools, it is crucial to develop methods for extracting representative and predictive information. READ MORE

7. 5. Diffuse large B-cell lymphoma - proteomic and metabolomic studies on prognosis and treatment failure

   Author : Martin Stenson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DLBCL; prognostics; proteomics; metabolomics;

   Abstract : Abstract Background and aim: Every year almost 600 patients in Sweden are diagnosed with diffuse large B-cell lymphoma (DLBCL), the most common lymphoma, and with immunochemotherapy, approximately 60 % are cured. Yet, for patients with primary refractory disease or early relapse, the prognosis is very poor. READ MORE