Search for dissertations about: "prefractionation"
Found 5 swedish dissertations containing the word prefractionation.
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1. Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
Abstract : ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer?s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact with the extracellular fluid of the brain and is consequently a valuable medium for identifying biomarkers for neurological disorders. READ MORE
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2. Biomarker detection via lab-on-a-chip integrated immunoaffinity approach for fluorescence and mass spectrometry readout
Abstract : The blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. READ MORE
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3. Cancer proteomics : method development for mass spectrometry based analysis of clinical materials
Abstract : To improve cancer treatment, biomarkers for diagnostics and therapeutic guidance are desperately needed. Mass spectrometry (MS) based proteomics is one of the most promising methods for biomarker discovery. Clinical materials such as blood and tumor tissue provide an excellent starting material for biomarker discovery studies. READ MORE
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4. Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells
Abstract : This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better understanding of regulatory mechanisms of individual cell types, both during normal development and during the onset and progression of diseases. READ MORE
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5. Development of proteomic methods for studying cerebrospinal fluid proteins involved in Alzheimer´s disease
Abstract : Alzheimer's disease (AD) is the most common cause of dementia in western countries. The main neuropathological findings in the AD brain are senile plaques, neurofibrillary tangles and degeneration of neurons and synapses. READ MORE