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Showing result 1 - 5 of 15 swedish dissertations matching the above criteria.

  2. 1. Exploring mammalian preimplantation development and pluripotency

    Author : John Paul Schell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Our current understanding of how stem cells arise and transition during embryonic development has been limited by analysis tools that have lacked single-cell, whole-genome resolution. This thesis emphasizes the use of novel techniques and cutting-edge technology to better evaluate the biological underpinning of stem cell dynamics in both mouse and human. READ MORE

  4. 2. Preimplantation genetic diagnosis : evaluation of results and experiences

    Author : Katarina Haapaniemi Kouru; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Preimplantation genetic diagnosis (PGD) is an established alternative for couples at high risk of having an affected child, with the advantage that the genetic testing is performed at the embryo stage and the couple can thereby avoid a pregnancy termination of an affected foetus. The disadvantage is that an IVF treatment is required, which can be a stressful experience. READ MORE

  5. 3. Genetic studies in early embryos with emphasis on preimplantation genetic diagnosis

    Author : Erik Iwarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : chromosomal abnormality 1 embryo fluorescent in situ hybridisation FISH 1 in vitro fertilisation IVF 1 preimplantation genetic diagnosis PGD ;

    Abstract : It has been estimated that as much as 70-80% of all human conceptions do not develop to term. A majority of clinically recognisable pregnancies, which are miscarried, contain chromosome abnormalities. However, data from very early embryo development are difficult to obtain. READ MORE

  6. 4. Safety and quality aspects of IVF - neonatal and maternal outcomes following advanced techniques

    Author : Erica Ginström Ernstad; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blastocyst transfer; frozen embryo transfer; vitrification; preimplantation genetic testing; neonatal outcome; maternal outcome;

    Abstract : Background: Singletons born following assisted reproductive technology (ART) have adverse neonatal outcome compared to singletons born following spontaneous conception (SC). Moreover, the women undergoing ART are at an increased risk of hypertensive disorders in pregnancy (HDP) and placental complications. READ MORE

  7. 5. Human ovarian follicles and oocytes : collection, cryopreservation, culture and gene expression

    Author : Pu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ovarian follicle; oocyte; follicular aspirate; organ culture; cAMP; cGMP; cryopreservation; microarray; human gene expression; embryonic stem cell; preimplantation;

    Abstract : Infertility affects approximately 15% of couples globally. The most effective treatment today is in vitro fertilization. However, not all couples can be helped with the current techniques. To achieve better success, techniques of storage and in vitro maturation of ovarian follicles have to be improved. READ MORE