Search for dissertations about: "premenopausal women"

Showing result 1 - 5 of 53 swedish dissertations containing the words premenopausal women.

  1. 1. Genetic polymorphisms, IGF-1, and oral contraceptive use in women from high-risk breast cancer families

    Author : Maria Henningson; Bröstca-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; familial breast cancer; premenopausal women; htSNP; GSTP1; polymorphism; BRCA1; BRCA2; IGF-1; oral contraceptives; CYP17; GSTT1; GSTM1;

    Abstract : Breast cancer is the most common cancer among Swedish women, affecting more than 7000 women each year. About 5-10% of all breast cancers are hereditary, with a monogenic inheritance pattern, but only 2-4% are explained by germline mutations in BRCA1 or BRCA2. BRCA1/BRCA2 mutation carriers have a 60-80% risk of developing breast cancer. READ MORE

  2. 2. Effects of Endogenous and Exogenous Hormones on the Female Breast : With Special Reference to the Expression of Proteoglycans

    Author : Gunilla Hallberg; Tord Naessén; Gunvor Ekman-Ordeberg; Ingemar Persson; Cecilia Magnusson; Eva von Schoultz; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast tissue; proteoglycans; mammographic density; oral contraceptives; androgen receptor; proliferation; apoptosis; extracellular matrix; premenopausal; Obstetrics and gynaecology; Obstetrik och gynekologi; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : This thesis aims to study the effects of endogenous and exogenous hormones and mammographic breast density (BD) on cellular markers in non-cancerous female breast tissue. Women on the waiting list for breast reduction plastic surgery were recruited (n = 79), and randomized to 2 months of hormone therapy or no therapy before surgery. READ MORE

  3. 3. Studies of hyperandrogenicity and the metabolic syndrome in premenopausal women

    Author : Fariba Baghaei; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : androgens; SHBG; HPA axis; abdominal obesity; insulin; HDL; metabolic syndrome; ovarian volume; PCOS; polymorphism; genetics; androgen receptor; estrogen receptor; aromatase;

    Abstract : An androgenic sex hormone profile appears to be a typical feature of the metabolic syndrome (MetS) and a powerful risk factor for the development of type 2 diabetes in women. The causes of relative hyperandrogenicity (HA) are not clearly defined. READ MORE

  4. 4. Impact of Lifestyle, Hormones, and Genes on Breast Cancer

    Author : Maria Hietala; Bröstca-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; BRCA1; BRCA2; androgen receptor; CAG; GGC; polymorphism; htSNP; oral contraceptives; testosterone; breast-feeding; prolactin; premenopausal women; CYP2D; complementary and alternative medicin; antidepressants;

    Abstract : Approximately 7000 women are diagnosed and 1500 women die from breast cancer in Sweden every year. The aim of this thesis was to study the interplay of polymorphisms, hormone levels, lifestyle, and the use of concomitant medication in relation to risk and prognosis in two cohorts: one composed of young healthy women from high-risk breast cancer families and the other of breast cancer patients from the general population. READ MORE

  5. 5. Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer

    Author : Sara Alkner; Bröstca-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; prognosis; treatment prediction; endocrine treatment; tamoxifen; coactivator; AIB1; PAX2; SRC; contralateral breast cancer; premenopausal; randomized trial; mode of detection; mammography.;

    Abstract : One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. READ MORE