Search for dissertations about: "preparative"

Showing result 1 - 5 of 66 swedish dissertations containing the word preparative.

  2. 1. Design of robust preparative chromatography

    Author : Marcus Degerman; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; sensitivity analysis; optimization; modeling; preparative chromatography; Design space; Control Space; uncertainty analysis;

    Abstract : This work presents a methodology for analyzing and optimizing preparative chromatographic processes. It uses a model-based approach to find the critical process parameters, analyze the control space and suggest a design space that can be registered with the regulatory agencies. READ MORE

  4. 2. Palladium catalyzed reactions involving -allyl intermediates : preparative and mechanistic aspects

    Author : Kenneth Granberg; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  5. 3. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    Author : Johan Lindholm; Torgny Fornstedt; Karin Caldwell; Karl-Gustaf Wahlund; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; Chemistry; Kemi;

    Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE

  6. 4. Aspects of the Design of Preparative Chromatography for Purification of Antibodies

    Author : David Karlsson; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; ion-exchange chromatography; adsorption kinetics; gels; model calibration; robustness analysis; optimisation; ESPI; diffusion; steric mass action; Langmuir MPM; antibodies; design; Preparative chromatography; modelling; proteins; Chemical technology and engineering;

    Abstract : The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. READ MORE

  7. 5. Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC

    Author : Robert Arnell; Torgny Fornstedt; Andreas Seidel-Morgenstern; Uppsala universitet; []
    Keywords : Analytical chemistry; Liquid chromatography; Preparative LC; Chiral LC; Multi-component LC; Adsorption isotherm; Tracer-pulse method; Inverse method; Inverse method on plateaus; Peak deformations; Chiral drug-protein interactions; Analytisk kemi;

    Abstract : This thesis concerns the development and validation of methods for characterization of multi-component preparative LC systems. Measurements of competitive adsorption isotherms are performed to gain detailed information about the interactions inside the chromatography column. READ MORE