Search for dissertations about: "primary cell culture"

Showing result 6 - 10 of 185 swedish dissertations containing the words primary cell culture.

  2. 6. In vitro Studies of β-cell Death and Survival. Modulation by Adenoviral Vectors and Bcl-2 Overexpression

    Author : Andreea Roxana Barbu; Nils Welsh; Decio Eiziric; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; cytokine; mitochondrial membrane potential; Bcl-2; Adenoviral vector; Adenovirus; IFN-α; Diabetes; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Type 1 diabetes is a multifactorial disease resulting from the selective destruction of insulin-producing β-cells within the pancreatic islets of Langerhans. The mechanisms of β-cell death are not fully understood but cytokines are important mediators of this process. READ MORE

  4. 7. Cell therapy for denervated tissue

    Author : Roine El-Habta; Ludvig J. Backman; Paul J. Kingham; Patrik Danielson; António Salgado; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue-derived stem cell; cell therapy; denervation; differentiation; myoblast; peripheral nerve injury; proliferation; regeneration; skeletal muscle; stromal vascular fraction; survival; tendon; cellforskning; cell research; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Background: Peripheral nerve injury results in denervation of tendons and muscles. The biology of denervated muscle has been well studied but little is known about the associated tendons. READ MORE

  5. 8. Interplay Between Cell of Origin and Oncogenic Activation in Glioma

    Author : Yiwen Jiang; Lene Uhrbom; Anders Persson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; PDGF; cell of origin; Sox5; glioma initiating cells; Oncology; Onkologi;

    Abstract : Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. READ MORE

  6. 9. Influence of neuromodulators and mechanical loading on pathological cell and tissue characteristics in tendinosis

    Author : Gloria Fong; Patrik Danielson; Alex Scott; Ludvig Backman; Paul Ackermann; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P; acetylcholine; transforming growth factor; neuromodulators; mechanical loading; tendinosis; anatomi; Human Anatomy;

    Abstract : Background: Tendinosis is a painful chronic, degenerative condition characterized by objective changes in the tissue structure of a tendon. Hallmark features in tendinosis tendons include increased number of cells (hypercellularity), extracellular matrix (ECM) degradation and disorganized collagen. READ MORE

  7. 10. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation

    Author : Luis Oliveros Anerillas; Peyman Kelk; Paul J. Kingham; Mikko Lammi; Jöns Hilborn; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; angiogenesis; biomaterial; bone marrow mesenchymal stem cells; bone regeneration; hydrogel; osteoinduction; osteogenesis; scaffold; type I collagen; 3D culture; biology; biologi; biomedical laboratory science; biomedicinsk laboratorievetenskap; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. READ MORE