Search for dissertations about: "primary sensory neuron"
Showing result 1 - 5 of 17 swedish dissertations containing the words primary sensory neuron.
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1. A sensory role for the cruciate ligaments : regulation of joint stability via reflexes onto the γ-muscle-spindle system
Abstract : Reflex effects evoked by graded electrical stimulation of the posterior articular nerves (PAN) of the ipsi- and contralateral knee joints were investigated using both micro-electrode recordings from 7 - motoneurones and recordings from single muscle muscle spindle afferents. Spindle afferent responses were also recorded using natural stimulation of different types of receptors, to elucidate if the articular reflexes onto the y -motoneurones were potent enough to significantly alter the muscle spindle afferent activity. READ MORE
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2. Signaling Mechanisms in the Neuronal Networks of Pain and Itch
Abstract : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. READ MORE
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3. The effects of neurotrophic substances on primary sensory neurons following peripheral nerve injury
Abstract : Sensory impulses from the periphery is transmitted by primary sensory neurons located in dorsal root and cranial nerve ganglia. The primary sensory neurons are phenotypically diverse with regard to their expression of various chemical components. READ MORE
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4. An exploration of the mechanisms behind peripheral nerve injury
Abstract : Despite surgical innovation, the sensory and motor outcome after peripheral nerve injury is incomplete. In this thesis, the biological pathways potentially responsible for the poor functional recoveries were investigated in both the distal nerve stump/target organ, spinal motoneurons and dorsal root ganglia (DRG). READ MORE
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5. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence
Abstract : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. READ MORE
