Search for dissertations about: "progressive neurodegenerative disease"

Showing result 1 - 5 of 131 swedish dissertations containing the words progressive neurodegenerative disease.

  2. 1. Parkinson’s disease : the prodromal phase and consequences with respect to working life

    Author : Helena Nyström; Anna Nordström; Peter Nordström; Kristian Winge; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; quality of life; employment; rehabilitation; prodromal phase; risk markers; depression; muscle strength; injurious fall; epidemiology;

    Abstract : Background: Parkinson’s disease (PD) is a common, progressive neurodegenerative disorder, recognized by the motor symptoms of bradykinesia, tremor, rigidity, and postural impairment. At clinical onset, extensive amounts of dopaminergic neurons have already been lost. READ MORE

  4. 2. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease

    Author : Andrea Boman; Katarina Kågedal; Samuel Svensson; Alan Sabirsh; Per Svenningsson; Oskar Hansson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrospinal fluid CSF ; biomarkers; therapeutic targets; neurodegeneration; Alzheimer’s disease AD ; Parkinson’s disease PD ; Corticobasal degeneration CBD ; Progressive supraneuclear palsy PSP ; Lysosomes; Endosomes; Autophagy; LAMP-2; Lysozyme;

    Abstract : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. READ MORE

  5. 3. Metabolomics studies of ALS : a multivariate search for clues about a devastating disease

    Author : Anna Wuolikainen; Peter M Andersen; Henrik Antti; Stefan L Marklund; Thomas Moritz; Thomas Hankemeier; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyotrophic lateral sclerosis ALS ; motor neuron disease; Lou Gehrig’s disease; human disease; CSF; biomarkers; metabolomics; metabonomics; chemometrics; design of experiments; multivariate analysis.; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, motor neuron disease (MND) and Lou Gehrig’s disease, is a deadly, adult-onset neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, resulting in evolving paresis of the linked muscles. ALS is defined by classical features of the disease, but may present as a wide spectrum of phenotypes. READ MORE

  6. 4. CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

    Author : Evangelos Konstantinidis; Martin Ingelsson; Anna Erlandsson; Vilmantas Giedraitis; Magnus Essand; Harald Steiner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Parkinson s disease; gene editing; CRISPR Cas9; amyloid-beta; astrocytes; neurons; iPSCs; electrophysiology;

    Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders. Whereas the AD brain features plaques of amyloid-beta (Aβ) and neurofibrillary tangles of tau, the PD brain is characterized by Lewy bodies and Lewy neurites containing α-synuclein (αSyn). READ MORE

  7. 5. Magnetic Resonance Imaging in Parkinsons's disease and related disoders

    Author : Yulia Surova; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mr Imaging; DTI; Parkinson s disease; Progressive supranuclear palsy; Multiple system atrophy;

    Abstract : Objectives: To identify diagnostic and prognostic biomarkers in the cerebral white (WM) and the deep grey matter (GM) in patients with Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS) using magnetic resonance imaging (MRI). Methods: Patients with a clinical diagnosis of PD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) were included in the study. READ MORE