Search for dissertations about: "proinsulin-to-insulin conversion"

Found 2 swedish dissertations containing the words proinsulin-to-insulin conversion.

  1. 1. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

    University dissertation from Diabetes and Endocrinology

    Author : Yuedan Zhou; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TCF7L2; rs7903146; Type 2 diabetes; β cell function; β cell survival; insulin secretion; proinsulin synthesis; proinsulin-to-insulin conversion; insulin maturation; open chromain; exon skipping; p53; TP53INP1; ISL1; MAFA; NEUROD1; PDX1; NKX6.1; PCSK1; PCSK2; SLC30A8; GWAS.;

    Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. READ MORE

  2. 2. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andreas Börjesson; Uppsala universitet.; [2008]
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Type 1 diabetes; proinflammatory cytokines; SOCS-3; pancreatic islets; inducible nitric oxide synthase; insulin secretion; NOD mice; islet transplantation; proinsulin conversion; streptozotocin; prolactin; VETERINARY MEDICINE Medicine; VETERINÄRMEDICIN Medicin;

    Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE