Search for dissertations about: "proinsulin"

Showing result 1 - 5 of 48 swedish dissertations containing the word proinsulin.

  2. 1. Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease : Clinical Epidemiological Studies with up to 27 Years of Follow-Up

    Author : Björn Zethelius; Björn Fagerberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; diabetes; coronary heart disease; insulin; proinsulin; prognosis; mortality; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Geriatrics; geriatrik;

    Abstract : Defects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules. READ MORE

  4. 2. The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin

    Author : Hans-Erik Johansson; Björn Zethelius; Arvo Hänni; Margareta Öhrvall; Lars Lannfelt; Claes-Göran Östenson; Uppsala universitet; []
    Keywords : Proinsulin; insulin; glucose; obesity; bariatric surgery; MEDICINE; MEDICIN;

    Abstract : Hyperproinsulinemia is associated with type 2 diabetes (T2DM) and obesity and is a predictor for future coronary heart disease. This thesis examines the effect of bariatric surgery on glucometabolic status including insulin and proinsulin responses after meal. READ MORE

  5. 3. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo

    Author : Quan Wen; Anders Forslund; Hannes Manell; Hjalti Kristinsson; Lisa Juntti-Berggren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha cell; carboxypeptidase E; childhood obesity; DRP-1; free fatty acids; glucagon secretion; glucose metabolism; glucose stimulated insulin secretion; human islets; hyperinsulinemia; metformin; mitochondrial fission; oral glucose tolerance test OGTT ; prohormone convertase; proinsulin; proinsulin to insulin ratio PI:I ;

    Abstract : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. READ MORE

  6. 4. Risk Factors for Stroke in Adult Men : A Population-based Study

    Author : Bernice Wiberg; Lars Lind; Johan Sundström; Björn Zethelius; Peter Appelros; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; risk factor; stroke; TIA; lipoproteins; fatty acids; insulin resistance; proinsulin; clamp; cognitive function; epidemiology; Trail Making Test; stroke mortality; dependency; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Medicinsk vetenskap; Medical Science;

    Abstract : In the last decades our knowledge concerning cardiovascular risk factors has grown rapidly through results from longitudinal studies. However, despite new treatment, in Western countries coronary heart disease remains the leading cause of death and stroke is still the leading cause of severe disability. READ MORE

  7. 5. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

    Author : Gabriella Brolén; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

    Abstract : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. READ MORE