Search for dissertations about: "proline isosteres"

Found 3 swedish dissertations containing the words proline isosteres.

  1. 1. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    University dissertation from Institutionen för fysik, kemi och biologi

    Author : Fredrik Thorstensson; Linköpings universitet.; Linköpings universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE

  2. 2. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    University dissertation from Institutionen för fysik, kemi och biologi

    Author : Fredrik Wångsell; Linköpings universitet.; Linköpings universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Abstract : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. READ MORE

  3. 3. Synthesis of a targeted library and thrombin inhibitors using organometallic chemistry

    University dissertation from Linköping : Linköpings universitet

    Author : Fredrik Thorstensson; Linköpings universitet.; Linköpings universitet.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The use of organometallic chemistry in the pursuit of novel scaffolds is outline d. A 4-phenyl- 2-carboxy-piperazine targeted combinatorial chemistry library has been synthesized aimed at the early lead discovery phase. READ MORE