Search for dissertations about: "proline"

Showing result 1 - 5 of 122 swedish dissertations containing the word proline.

  2. 1. The Role of Proline Catabolism in Candida albicans Pathogenesis

    Author : Fitz Gerald S. Silao; Per O. Ljungdahl; Joachim Morschhäuser; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Candida albicans; proline metabolism; ATP; P5C; virulence; macrophage; hyphae; filamentation; Ras1 cAMP PKA; mitochondria; Proline dehydrogenase; P5C dehydrogenase; reactive oxygen species; Proline-P5C cycle; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Candida albicans is an opportunistic fungal pathogen that has evolved in close association with human hosts. Pathogenicity is linked to an array of virulence characteristics expressed in response to environmental cues and that reflect the requirement to take up and metabolize nutrients available in the host. READ MORE

  4. 2. Biotic and abiotic stress in microorganisms and plants: Some Mechanisms of Stress and Programmed Cell Death. Genetic Engineering Approaches Towards Improved Stress Tolerance

    Author : Per-Johan Meijer; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biotic stress; plants; microorganisms; stress tolerance; antifreeze protein; proline; programmed cell death; systemic aquired resistance; Biochemistry; metabolism; Biokemi; Bioteknik; Biotechnology; abiotic stress;

    Abstract : Various forms of stress, such as biotic and abiotic stress, were studied in microorganisms and plants to learn more about the underlying mechanisms of such stress and potential genetic engineering strategies towards stress tolerance. An antifreeze protein from winter flounder, expressed in E. READ MORE

  5. 3. The Cyanophyte Arthrospira Fusiformis in African Waters - Eco-Physiology and Potential Use in Tropical Aquaculture

    Author : Aidate Mussagy; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; limnology; Marinbiologi; marine biology; aquatic ecology; lipopolysaccharide endotoxins LPS ; salinity; osmoregulation; proline; aquaculture feeds; Artemia.; Hydrobiology; anatoxin; microcystin; ITS sequences; phenotype analysis; taxonomy; Cyanophyceae; Arthrospira fusiformis; limnologi; akvatisk ekologi;

    Abstract : The cyanoprokaryote (blue-green algae) genus Arthrospira occurs in saline, alkaline tropical waters of Africa, Asia, and Central America. Traditionally Arthrospira has been used as a food supplement by the Kanembu tribe of Lake Chad and Aztecs living in the valley of Mexico City. READ MORE

  6. 4. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    Author : Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

    Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE

  7. 5. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

    Author : Inga Dikic; Olli Silvennoinen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. READ MORE