Search for dissertations about: "prolyl hydroxylases"

Found 3 swedish dissertations containing the words prolyl hydroxylases.

2. 1. Analysis of HIF-1alpha degradation and function

   Author : Helder André; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Hypoxia-inducible factor-1alpha; protein degradation; prolyl hydroxylases; adenoassociated virus; gene therapy; angiogenesis.;

   Abstract : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. READ MORE

4. 2. Skeletal muscle HIF-1 and exercise

   Author : Helene Rundqvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Regular physical activity prevents and improves a number of disease conditions and reduces the risk for premature death substantially. From a clinical as well as a basic science point of view it is important to create a more fundamental understanding of the molecular mechanisms that contribute to the improved functional capacity induced by regular physical activity. READ MORE

5. 3. Regulators of angiogenesis in diabetes and tumors

   Author : Sergiu-Bogdan Catrina; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Diabetes; HIF; hypoxia; tumors; growth factors; wound healing;

   Abstract : Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular energy level and the potential risk of cellular oxidative damage. READ MORE