Search for dissertations about: "promoter selectivity"

Showing result 1 - 5 of 9 swedish dissertations containing the words promoter selectivity.

  2. 1. Molecular mechanism of cell regulatory properties of vitamin D analogues in human cancer cell lines

    Author : Carina Danielsson; Uppsala universitet; []
    Keywords : Medical sciences; vitamin D analogues; retinoids; cancer cell lines; promoter selectivity; cellregulatory properties; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Abstract : The active form of vitamin D, 1α,25-dihydroxyvitamin D3, is a potent modulator of the induction of differentiation and inhibition of cell growth in both malignant and normal cells. Vitamin D and its analogues exert their effects through a transcription factor, the nuclear vitamin D receptor (VDR). READ MORE

  4. 2. Molecular mechanisms of estrogen and antiestrogen action

    Author : Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Abstract : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. READ MORE

  5. 3. Studies of penta-decameric binding proteins: AP-4 and CBF-A

    Author : Alaitz Aranburu; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; transplantation; Metabolism; serologi; metabolism; Biokemi; serology; Immunology; hnRNP H; NPM; CBF-A; AP-4; transcription; B cells; immunoglobulin; Immunologi;

    Abstract : Each immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. READ MORE

  6. 4. Estrogen signaling in metabolic disease : a functional genomics approach

    Author : Hui Gao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : estrogen receptor; insulin sensitivity; functional genomics; mouse liver; lipid metabolism;

    Abstract : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. READ MORE

  7. 5. Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms

    Author : Sabine Uhles; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Insulin receptor; signal transduction; gene expression regulation; insulin; glucokinase; cfos; pancreatic beta cell; membrane microdomains; green fluorescent protein.;

    Abstract : Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently discussed as the result of the activation of specific signal transduction pathways. READ MORE