Search for dissertations about: "proneural genes"

Showing result 1 - 5 of 10 swedish dissertations containing the words proneural genes.

  2. 1. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

    Author : Elin Andersson; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

    Abstract : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. READ MORE

  4. 2. Regulation of neurogenesis in the vertebrate CNS

    Author : Magdalena Källström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During development, neurons are generated from self-renewing progenitor cells in the ventricular zone of the neural tube. Proneural bHLH proteins are involved in the regulation of neurogenesis and can direct the exit of neural progenitors from the cell cycle and promote the expression of downstream differentiation markers. READ MORE

  5. 3. From stem cell to neuron : a Sox perspective

    Author : Maria Bergsland; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The differentiation of stem cells into the more than 100 billion neurons that compose the central nervous system (CNS) is one of the most remarkable transformations during vertebrate development. A central problem of this process is how neural lineage selection initially is specified in pluripotent stem cells and maintained during the course of neurogenesis. READ MORE

  6. 4. Sox proteins and neurogenesis

    Author : Magnus Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The primordium of the central nervous system is specified in a process called neural induction at which point the ectoderm is subdivided into the epidermal ectoderm and the neural plate. With time the neural plate will thicken, fold and form the neural tube. READ MORE

  7. 5. Regional control of cell fate determination and neurogenesis in the developing CNS

    Author : Ulrika Marklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The development of a functional central nervous system relies on the generation of distinct neuronal subtypes in a spatially and temporally defined order. The spatial organisation is achieved at early developmental time points when neural progenitor cells encounter fields of secreted morphogenic signalling molecules along the anterioposterior and dorsoventral axes of the embryo. READ MORE