Search for dissertations about: "prostaglandin E synthase"

Showing result 1 - 5 of 33 swedish dissertations containing the words prostaglandin E synthase.

  1. 1. Studies of prostaglandin E2 formationin human monocytes

    Author : Sofia Karlsson; Jonny Wijkander; Christina Gustafson-Svärd; Karlstads universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin E2; arachidonic acid; phospholipase A2; cyclooxygenase; prostaglandin E synthase; human monocytes; Medical cell biology; Medicinsk cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Prostaglandin (PG) E2 is an eicosanoid derived from the polyunsaturated twenty carbon fatty acid arachidonic acid (AA). PGE2 has physiological as well as pathophysiological functions and is known to be a key mediator of inflammatory responses. READ MORE

  2. 2. Structure and Function of Microsomal Prostaglandin E Synthase-1

    Author : Sven-Christian Pawelzik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, and the concerted action of both enzymes leads to the production of induced prostaglandin E2 (PGE2), a potent lipid mediator of inflammation, pain, and fever. READ MORE

  3. 3. Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1

    Author : Staffan Thorén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. READ MORE

  4. 4. Prostaglandin E2 in Brain-mediated Illness Responses

    Author : Louise Elander; Anders Blomqvist; Marianne Schultzberg; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostaglandin e2; PGE2; cox-1; cox-2; mPGES-1; fever; anorexia; food intake; HPA-axis; EP-receptor; LPS; IL-1; IL-6; MEDICINE; MEDICIN; Neurobiology; Neurobiologi;

    Abstract : We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. READ MORE

  5. 5. Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1: inhibition and mechanism

    Author : Linda Spahiu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is a family of six membrane bound proteins with different biological functions. MAPEG superfamily members enable and catalyze reactions where reactive lipid intermediates are either transformed to physiological messengers or turned into unreactive compounds. READ MORE